有机药物中残留三氟醋酸测定方法的研究  

STUDY ON TEST METHOD OF RESIDUAL TRIFLUOROACETIC ACID IN ORGANIC DRUG SUBSTANCES

作　　者：张莉[1] 晁若冰[1] 

机构地区：[1]四川大学华西药学院,四川成都610041

出　　处：《华西药学杂志》2001年第6期427-428,共2页West China Journal of Pharmaceutical Sciences

摘　　要：目的 :检查有机药物中残留的溶剂三氟醋酸。方法 :将药物进行氧瓶燃烧破坏后 ,用茜素氟蓝比色法测定氟 ,再换算成三氟醋酸的量。结果 :检测限为 4.6 μg的三氟醋酸 ,线性范围为 5～ 30 μg氟 (r=0 .9990 ) .结论 :该检查方法较简便 ,灵敏 。OBJECTIVE:To determine the amount of residual organic solvent trifluoroacetic acid in organic drug substances.METHODS:The sample was decomposed by oxygen flask combustion method. The fluorine was determined by colorimetry and the corresponding amount of trifluoroacetic acid was calculated.RESULTS:Detection limit of the method was 4.6 μg trifluoroacetic acid; calibration curve was linearity within the range of 5～30 μg fluorine ( r =0.9990).CONCLUSION:The method is simple , sensitive , reliable and applicable to determine residual trifluoroacetic acid in organic drug substances.

关 键 词：残留有机溶剂 三氟醋酸 氧瓶燃烧法 苯素氟蓝比色法 限量检查 有机药物 测定 

分 类 号：R917[医药卫生—药物分析学]