枸杞多糖对2型糖尿病患者T淋巴细胞亚群和细胞因子的调节作用  

Regulating effect of Lycium Barbarum Polysaccharide on T lymphocyte subpopulation and cytokines in patients with type-2 diabetes

作　　者：王玲[1] 张才军[1] 李维波[1] 蒋绿芝[2] 谢蒲伶[1] 邓学端[1] 

机构地区：[1]昆明医学院,650031 [2]昆明医学院第二附属医院,650101

出　　处：《河北中医》2001年第12期888-890,共3页Hebei Journal of Traditional Chinese Medicine

基　　金：云南省教委应用研究基金及昆明医学院骨干教师基金资助课题(编号 :96 12 117)

摘　　要：目的　研究枸杞多糖 (LBP)对 2型糖尿病患者T淋巴细胞亚群和细胞因子水平的调节作用。方法　 2 0例 2型糖尿病患者与 2 0例正常人对照 ,2型糖尿病患者口服LBP ,每次40 0mg,每日 2次 ,连续 1 4日 ,第 1 5日检测T淋巴细胞亚群 (APAAP法 )、白细胞介素 2 (IL 2 )和白细胞介素 6(IL 6) (ELISA法 ) ,比较用药前后LBP对 2型糖尿病患者T淋巴细胞亚群、IL 2和IL 6水平的调节作用。结果　 2型糖尿病患者T8和T4/T8用药前与对照组比较有显著性差异 (P <0 .0 1 )。2型糖尿病患者用药后T8比用药前明显下降 ,T4/T8显著升高 (P <0 .0 1 ) ,接近正常。 2型糖尿病患者用药前与正常对照组比较IL 2水平明显下降 ,IL 6水平升高 (P <0 .0 1 ) ;用药后与用药前比较 ,IL 2水平明显增高 ,IL 6则降低 (P <0 .0 1 ) ,二者均接近正常。结论　LBP对 2型糖尿病患者的T8和IL 6有明显的下调作用 ,并能明显增高IL 2的水平 ,LBP对Objective To study the regulating effect of Lycium Barbarum Polysaccharide(LBP) on T lymphocyte subpopulation and cytokines in patients with type 2 diabetes. Methods FLP was orally taken by 20 patients in experiment group,400mg once,twice a day,lasting for 14 days.On the fifteenth day T lymphocyte subpopulation,interleukin 2(IL 2) and interleukin 6(IL 6) were detected by APAAP and ELISA methods respectively.20 healthy subjects serve as the control group. Results There was significant difference in T 8 and T 4/T 8 between the patients with type 2 diabetes before treatment and healthy subjects (P<0.01) . The T 8 in patients with type 2 diabetes was decreased significantly,whereas T 4/T 8 was increased obviously (P<0.01) .The level of IL 2 in patients with type 2 diabetes before treatment was decreased notably,while the level of IL 6 was increased significantly;but the results after treatment were just opposite to those before treatment. Conclusion LBP has obvious immunomodulary effect on patients with type 2 diabetes, which can reduce T 8 and IL 6,and increase IL 2 significantly.

关 键 词：枸杞多糖 2型糖尿病 T淋巴细胞亚群 细胞因子 治疗 

分 类 号：R587.1[医药卫生—内分泌] R285.6[医药卫生—内科学]