诱导痰液分析在咳嗽变异性哮喘诊断中的应用  

Diagnosis of cough variant asthma by sputum induction analysis

作　　者：聂国明 刘雪梅[1] 蔡根秀[1] 宋湘豫[1] 

机构地区：[1]广州军区武汉总医院,武汉430070

出　　处：《临床内科杂志》2002年第1期22-24,共3页Journal of Clinical Internal Medicine

摘　　要：目的　探讨咳嗽变异性哮喘 (CVA)患者是否存在气道炎症。方法　采用 3%～ 5 %的高渗盐水超声雾化吸入诱导排痰 ,对 35例临床诊断为CVA的患者痰液进行肥大细胞 (MC)百分率、嗜酸性粒细胞 (EC)百分率、嗜酸性粒细胞阳离子蛋白 (ECP)及中性粒细胞 (N)进行检测 ,并同步测定 1s用力呼气容积 (FEV1)及 1s用力呼气占预计值百分比 (FEV1占预计值 % )。结果　 35例临床诊断为CVA的患者 ,其痰液中MC、EC百分率、ECP浓度、FEV1及FEV1占预计值 %与对照组比较 ,差异均具有显著性 (P <0 .0 5 ) ,与典型支气管哮喘比较差异无显著性 (P >0 .0 5 )。经抗炎治疗后咳嗽症状很快缓解 ,复测痰液中MC、EC百分率、ECP浓度、FEV1及FEV1占预计值 %与治疗前比较 ,差异有显著性。结论　痰液分析从实验室角度阐明CVA存在气道炎症 。Objective To determine whether the patients with CAV have respiratory inflammation.Methods Using inducing antiphlegm with inspiring ultrasonic atomized hypertonic saline, the percents of MC and EC, ECP and N in the phlegm of the 35 patients with CAV were detected, as well as FEV 1 and FEV 1/predicted value% were detected.Results There were significant difference between the percents of MC and EC, ECP and N, FEV 1 and FEV 1/predicted value% in the phlegm of the 35 patients with CAV comparde with that those in control group. Through anti inflammation treatment, cough was released.Conclusion The phlegm analyzing clarify that CAV has respiratory inflammation and providing a reliable data for clinic diagnosis and therapy.

关 键 词：咳嗽变异性哮喘 诊断 痰液分析 炎症细胞 

分 类 号：R562.25[医药卫生—呼吸系统]