生长激素缺乏症治疗后骨龄的变化  

Effect of the Therapy on Bone Age in Patients with Growth Hormone Deficiency

作　　者：江静[1] 王伟[1] 王德芬[1] 谢吉[2] 

机构地区：[1]上海第二医科大学瑞金医院儿内科,上海200025 [2]上海第二医科大学瑞金医院放射科,上海200025

出　　处：《上海第二医科大学学报》2002年第1期47-49,共3页Acta Universitatis Medicinalis Secondae Shanghai

摘　　要：目的研究原发性生长激素缺乏症 (GHD)治疗 2 4个月后身高年龄 (HA)和骨龄的变化。　方法 17例GHD伴促性腺激素缺乏的男性患者 ,年龄 14.8± 2 .2 7岁 ,HA 8.16± 1.5岁 ,给予重组人生长激素 (rhGH ,健高宁 )治疗2 4个月 ,第 13个月起合用绒毛膜促性腺激素或庚酸睾酮 ,观察疗效。　结果治疗第 1年 ,生长速率 (HV) 11.2 5±1.89cm/年 ,身高年龄增加 (ΔHA) 2 .13± 0 .36岁 ,骨龄增加 (ΔBA) 2 .17± 0 .5 7岁 ,ΔHA/ΔBA 1.0 6± 0 .36 ;第 2年 ,HV13.39± 2 .5 2cm/年 ,ΔHA 2 .18± 0 .5 9岁 ,ΔBA 2 .0 5± 0 .8岁 ,ΔHA/ΔBA 1.13± 0 .2 9。患者治疗前、治疗后不同阶段的HA皆与BA呈正相关 ;两年身高标准差积分 (HtSDS)增加 2 .5 5。　结论单用rhGH和合用性激素治疗均对GHD患者有明显的促线性生长和发育作用 ,并且后者效果更佳 ;在促身高增加的同时也促骨龄成熟 ,而且两者平行。Objective To find the relationship between height age and bone age in patiens with growth hormone deficiency (GHD)after two year treatment. Methods 17 GHD patients with gonadotropin deficiency [age 14.80±2.27 years, height age (HA)8.16±1.5 years] received imported recombinant human growth hormone (rhGH) for 24 months, and chorionic gonadotropin or testoviron depot in the second year. Results In the first year, height velocity (HV) was 11.25±1.89 cm/year, HA increased (ΔHA) 2.13±0.36 years. Bone age increased (ΔBA) 2.17±0.57 years with ΔHA/ΔBA 1.06±0.36. In the second year, HV was 13.39±2.52cm/year, ΔHA 2.18±0.59 years,ΔBA 2.05±0.8 years, ΔHA/ΔBA 1.13±0.29. HA had a direct proportion to BA before and after 6, 12, 18, 24 months. Within two years, height added 2.55 SDS. Conclusion rhGH alone or with sex hormone both had obvious effect on promoting growth and development of GHD patients, the latter being more efficient. The growth is in accordance with maturity.

关 键 词：生长激素缺乏症 重组人生长激素 身高 年龄 骨龄 治疗 

分 类 号：R725.8[医药卫生—儿科]