使用二元环糊精体系毛细管电泳法分离手性药物  

Enantiomeric Separations of Chiral Drugs with Dual Cyclodextrin Systems in Capillary Electrophoresis

作　　者：张锴[1] 张智超[1] 王琴孙[1] 高如瑜[1] 

机构地区：[1]南开大学元素有机化学研究所元素有机国家重点实验室,天津300071

出　　处：《分析化学》2002年第2期172-174,共3页Chinese Journal of Analytical Chemistry

基　　金：天津市自然科学基金(No.9836033ll);国家自然科学青年基金(No.29907002)

摘　　要：采用高效毛细管区带电泳法，分别以羟丙基－β－环糊精（ＨＰ－β－ＣＤ）和高磺化－β－环糊精（ＨＳ－β－ＣＤ）及二者混合物为手性选择剂，研究了５种药物的对映体分离，并取得很好的对映体分离结果。比较了ＨＰ－β－ＣＤ和ＨＳ－β－ＣＤ手性识别能力，分析了二元环糊精体系的“协同效应”。Enantiomeric separations of 5 chiral drugs with 2 chial resolving agent, hydroxypropyl-beta-cyclodextrin (BP-beta-CD), highly sulfated-beta-cyclodextrin (HS-beta-CD) and mixture of them, as chiral additives by capillary zone electrophoresis ( CZE) were investigated, and the good enantiomeric separations of 5 drugs were obtained successfully. Chiral recognition of HS-beta-CD was compared with HP-beta-CD. Synergistic effect of dual cyclodextrins systems in chiral capillary electrophoresis was investigated.

关 键 词：毛细管电泳 对映体分离 协同效应 手性药物 羟丙基-Β-环糊精 高磺化-β-环糊精 

分 类 号：O658.9[理学—分析化学]