钙通道阻滞药与心肌顿抑  

Calcium channel blockers and myocardial stunning

作　　者：李英茜[1] 龚培力[1] 

机构地区：[1]同济医科大学临床药理研究所,湖北武汉430030

出　　处：《中国新药与临床杂志》2002年第1期39-42,共4页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：心肌顿抑是指短暂缺血后可逆性心肌收缩功能异常 ,是再灌注损伤的一种形式 ,临床上常出现该现象。钙通道阻滞药是心血管疾病常用药物 ,目前大量研究证明可以抑制心肌顿抑。本文综述了钙通道阻滞药治疗心肌顿抑的实验证据。Myocardial stunning refers to the reversible dysfunction of myocardial contractility after temporary ischemia,is one form of the reperfusion injuries and is a phenomenon which often occurs in clinical practice. Calcium channel blockers are drugs often used in cardiovascular diseases and have been proved by a lot of studies that they can inhibit myocardial stunning. This review expounds problems on the therapy of myocardial stunning by calcium channel blockers in the aspects such as the proof of experiment, the basis of theory and the clinical application.

关 键 词：钙通道阻滞药 心肌顿抑 尼索地平 心肌再灌注损伤 

分 类 号：R541.4[医药卫生—心血管疾病] R972.3[医药卫生—内科学]