血小板CD62p在突发性聋治疗中的意义  

Significens of blood platelet CD62p in treating sudden deafness

作　　者：张芩娜[1] 张丽萍[2] 夏立军[1] 陈彦球[1] 王建明[1] 王斌全[1] 

机构地区：[1]山西医科大学第一医院耳鼻咽喉科,太原030001 [2]山西医科大学第二医院耳鼻咽喉科

出　　处：《中华耳鼻咽喉科杂志》2002年第1期27-29,共3页Chinese Journal of Otorhinolaryngology

摘　　要：目的　根据血小板细胞黏附分子CD6 2p的变化 ,为突发性聋患者的治疗提供有用的指标。方法　 15 6例突发性聋患者血小板CD6 2p采用流式细胞仪测定 ,将血小板CD6 2p≥ 2 %患者分别施以基础治疗 (低分子右旋糖甙 +ATP +CoA +地塞米松 )和基础治疗 +溶栓 (巴曲酶 ) ,观察 2种方案的疗效 ,同样血小板CD6 2p <2 %患者亦施以两种治疗方案观察其疗效。结果　在血小板CD6 2p≥ 2 %组中 ,基础治疗有效率为 6 0 5 % ,基础治疗 +溶栓治疗的有效率为 84 6 % ,两者之间差异有显著性。而在血小板CD6 2p <2 %组中 ,基础治疗和基础治疗 +溶栓的有效率分别为 6 5 0 %、71 8% ,差异无显著性。结论　检测突发性聋患者CD6Objective To compare different treatment methods for sudden deafness of different blood platelet CD62p levels. Methods Blood platelet was measured with flow cytometer. Patients with platelet CD62p over or less than 2% were treated with routine treatment (low molecular weight dextran, ATP, CoA and dexamethasone) or routine treatment plus batroxobin (thrombolysis) separately. Results In the group with platelet CD62p≥2%, the effective rates of routine treatment was 60.5%, and that of routine treatment plus thrombolysis was 84.6%. There was significant difference between them. In the group with platelet CD62p <2%, the effective rates of two methods were 65.0% and 71.8% respectively(no significant difference between them). Conclusions Detecting CD62p in sudden deafness patients makes sense for deciding treatment project.

关 键 词：突发性耳聋 细胞黏着分子 血栓溶解治疗 血小板CD62P 

分 类 号：R764.43[医药卫生—耳鼻咽喉科]