泰能与菌必治治疗新生儿败血症的对照研究  

Contrast study on Tienam and Rocephin treating neonatal septicemia

作　　者：吴俊[1] 

机构地区：[1]暨南大学医学院第二附属医院儿科,518020

出　　处：《广州医药》2002年第1期43-45,共3页Guangzhou Medical Journal

摘　　要：目的 :研究泰能与菌必治对照治疗新生儿败血症的疗效。方法 :对 98例血培养阳性的新生儿败血症患者分别给予泰能 (5 5例 )每次 15mg/kg,每 6h 1次 ,每天 4次 ;菌必治 (43例 )每天 5 0mg/kg ,每天 1次。于治疗第 7、10天或第 14天复查血培养。结果 :①　共培养细菌 110株 ,单一感染 86例 ,混合感染 12例。革兰氏阳性菌 79株(71 8% ) ,革兰氏阴性菌 31株 (2 8 2 % )。金黄色葡萄球菌 18株 (16 4 % ) ,凝固酶阴性葡萄球菌 5 2株 (47 3% ) ,粪肠球菌 3株 (2 7% ) ,粪链球菌 2株 (1 8% ) ,无乳链球菌 2株 (1 8% ) ,蜡样芽胞杆菌 2株 (1 8% ) ,大肠埃希氏菌 14株 (12 7% ) ,阴沟肠杆菌 8株 (7 3% ) ,肺炎克雷伯杆菌 4株 (3 6 % ) ,黄杆菌 2株 (1 8% ) ,变形杆菌 2株 (1 8% ) ,干燥棒状杆菌 1株 (0 9% )。②　菌必治组的临床治愈率、细菌清除率、平均住院时间分别为 78 2 %、 78 2 %、 14 4±2 31d ;泰能组则分别为 93%、 93%、 10 5± 2 16d。两组相比P分别 <0 0 5和 0 0 1,有显著差异。结论 :①　新生儿败血症以葡萄球菌尤以凝固酶阴性葡萄球菌为主。②　泰能治疗敏感细菌所致新生儿败血症临床疗效显著、细菌清除率高 ,副作用小。Objective:To study the effect of Tienam and Rocephin treating neonatal septicemia Methods:98 cases,which were identified positive by blood culture,were divided into two groups The Tienam group (55 cases) were gived Tienam 15 mg/kg,per time,one time every 6 hours The total were 4 times a day The Rocephin group (43 cases) were gived Rocephin 50 mg/kg,per day,once daily If the con dition of the neonatal did not improve or becamed worse within 3 days or blood culture showed the bacteria infected were not sensitive to Tienam or Rocephin,the treating plan would be changed According to the clinical expression,the blood culture would be retested in 7 or 10 or 14 days Results:① The blood culture showed 110 strains of bacteria Single infection were 86 cases and mixed infection were 12 cases 79 strains (71 8%) were of Grans positive,but 31 (21 8%) Grans negaive The bacteria were S aureus 18 strains,caogulase negative staphylococcus 52,E faeocalis 2,S faocalis 2,S agalactiae 2,Bacillus cereus 2,Escherichia coli 14,E cloalae 8,K pneumaniae 4,F lavobacterium 2,P vulgaris 2,C xerosis 2 2,The clinical curing rate,bacterium clearing rate,average inhospitalization time of Rocephin group was 78 2%,78 2%,14 4±2 31 days separately,but which of Tienam group was 93%,93%,10 5±2 16 days separately, P <0 05 and 0 01 Its were significant statistically Conclusions:① The bacteria of Neonatal septicemia are composed of staphylococcus especially caogulase negative staphylococcus mainly ② It has a high clinical efficacy and a high bacterium clearing rate,and has a few side effects that Tienam treat neunatal septicemia which is infected by sensitive bacteria

关 键 词：泰能 菌必治 新生儿败血症 治疗 

分 类 号：R722.131[医药卫生—儿科]