皮肤撕脱伤后丙二醛含量变化及其意义  

INVESTIGATE OF MDA IN SERUM AND AVULSED TISSUE AFTER SKIN AVULSION INJURY

作　　者：郭树忠[1] 鲁开化[1] 张琳西[1] 

机构地区：[1]第四军医大学西京医院整形外科中心,西安710032

出　　处：《中国美容医学》2001年第6期477-479,共3页Chinese Journal of Aesthetic Medicine

基　　金：国家自然科学基金资助项目 (39470 70 5 )

摘　　要：目的 :研究氧自由基在皮肤撕脱伤组织继发坏死中的作用。　方法 :用自行研制的皮肤撕脱伤模型机复制猪后肢皮肤撕脱伤模型 ,分别测定了正常、伤后 1、 2、 4、 8、 12、 2 4小时血清、撕脱皮肤和皮下组织中的丙二醛 (MDA)含量 ,绘制了其时间变化曲线。　结果 :皮肤撕脱伤后 2 4小时内组织和血清中丙二醛含量均显著升高 ,其变化有一定的规律。　结论 :皮肤撕脱伤后组织中脂质过氧化反应增强 。Objective:To investigate the role of the free radicals in the necrosis of avulsed tissue after skin avulsion injury Methods:To mimicked traffic accident,a machine was developed An avulsion injury model was created in hind leg of pig The malanyldialehyde(MDA)in serum and avlused tissue was measured 1,2,4,8,12,24 hours after trauma Results:The MDA in serum and avlused tissue increased constantly after injury Conclusion:The free radicals may play a very important role in the necrosis of avulsed tissue

关 键 词：皮肤撕脱伤 丙二醛 自由基 

分 类 号：R641.02[医药卫生—外科学]