糖尿病患者甲状腺自身免疫抗体的观察  

Observation of anti-thyroid auto antibodies in diabetes mellitus patients

作　　者：叶静[1] 张鹏[2] 陆凤仙[1] 汤特[1] 张天庚[1] 高淑伟[2] 赵秀琴[2] 

机构地区：[1]天津医科大学病生理教研室,300070 [2]天津医科大学总医院内分泌科

出　　处：《天津医科大学学报》2001年第4期494-496,共3页Journal of Tianjin Medical University

摘　　要：目的 :探讨糖尿病患者血清中的甲状腺自身免疫抗体水平。方法 :利用天津医科大学病生理教研室研制的TgAb、TPOAb、TRAb和TSI的ELISA试剂盒对35例1型糖尿病患者血清和60例2型糖尿病患者血清,以及40例正常人血清进行检测 ,测定数据经统计学处理 ,u检验。结果 :Type2DM和Type1DM组的TgAb、TPOAb、TRAb和TSI的阳性率显著高于正常组 (P<0.001)。Type1DM组也显著高于Type2DM组(P<0.05) ,Type1DM组甲状腺抗体的阳性率与文献报道的自身免疫甲状腺疾病 (AITD)的甲状腺抗体的阳性率接近。结论 :Type1DM和AITD同属自身免疫内分泌紊乱 ,二者之间有一定的联系 ,Type2DM患者的甲状腺抗体阳性率高于正常人 。Objective: To observe the correlation between diabetes mellitus and AITD(autoimmune thyroid disease),the 95 cases of diabetes were given the tests of the level of thyroid auto antibodies in their sera.Methods: The sera of 35 patients with insulin-independent diabetes mellitus(IDDM orTypeI),60 patients with noninsulin-depend diabetes mellitus (NIDDM or Type II) and 40 normal subjects have all been tested using our section developed TgAb?TPOAb?TRAb and TSI ELISA kits.Results: The positive ratios of TgAb?TPOAb?TRAb and TSI in NIDDM and IDDM groups are significantly higher than that of normal person group(P<0.001),The ratios in IDDM are significantly higher than that in NIDDM group too (P<0.05).The positive ratios of IDDM anti-thyroid autoantibodies are close to that of AITD patients reported by referential literatures. Conclusion: Both IDDM and AITD belong to autoimmune-endocrine disorders, suggesting some correlation between them.The facts that positive ratios of thyroid auto antibodies in NIDDM are higher than that in normal person may be one of the consequences caused by long-term immune systems modulation disorder in diabetes patients.

关 键 词：糖尿病 甲状腺自身免疫抗体 自身免疫性疾病 

分 类 号：R587.1[医药卫生—内分泌]