免疫失衡动物模型复制初探  

Preliminary studies on establishing the animal model of immune disorder

作　　者：马玲[1] 王红梅[1] 闫向东[1] 郑珊[1] 

机构地区：[1]北京市疾病预防控制中心,北京100013

出　　处：《中国食品卫生杂志》2001年第6期11-13,共3页Chinese Journal of Food Hygiene

摘　　要：为了进一步完善免疫失衡动物模型的复制方法 ,研究了不同剂量的环磷酰胺和氢化可的松对小鼠免疫功能的影响 ,并比较了二者对各项免疫指标抑制程度的差异。结果证明 ,在相同剂量下 ,氢化可的松对小鼠细胞免疫功能和巨噬细胞吞噬功能方面的抑制力大于环磷酰胺 ,而环磷酰胺对体液免疫功能的影响要强于氢化可的松 ,这提示了在复制免疫失衡动物模型时 ,针对不同免疫细胞可分别选择不同剂量的环磷酰胺或氢化可的松作为诱导剂。The effects of cyclophosphamide and hydrocortisone on mice immune system at different doses were observed to develop the model of immune disorder.The inhibition levels of two agents on immune system were compared.The results show that the inhibition ability of hydrocortisone on cellular immunity and macrophage function is higher than that of cyclophosphamide,on humoral immunity,the latter is stronger.Above all,the different targets we focus on,which are immunocyte,should be considered when we select cyclophosphamide or hydrocortisone at a special dose. Author's address: Ma Ling,the Beijing Municipal Center for Disease Prevention and Control,100013 PRC.

关 键 词：免疫学 免疫抑制 环磷酰胺 氢化可的松 免疫失衡动物模型 复制方法 

分 类 号：R392.1[医药卫生—免疫学]