脂肝清对高胆固醇血症家兔模型脂质代谢影响的实验研究  

Anexperiment research on the effect of ZhiGan Qing on lipid metabolism in the hypercholesterolaemia model of rabbit

作　　者：张吉正[1] 范英昌[1] 张伯礼[1] 徐宗佩[1] 

机构地区：[1]天津中医学院,300193

出　　处：《天津中医》2001年第6期29-31,共3页Tianjin Journal of Traditional Chinese Medicine

摘　　要：目的 :明确中药脂肝清对高脂血症防治作用 ,探讨其作用机制。方法 :以饲喂高脂饲料复制高胆固醇血症家兔模型 ,观察血清和肝脂质代谢 ,并且采用脂肝清进行预防实验 ,同时与一类降脂药洛伐他汀 (Lovastatine)作对照。结果 :1)中药明显降低血清TC、LDL C、TC/HDL C比值 (P<0 01或P<0 05) ,降低血清氨基转移酶活力 (P<0 01)。2)中药明显降低肝TC、TG及LDL C含量。结论 :脂肝清具有调整血清脂质代谢 ,促进肝组织中脂质的排泄及保护肝功能等作用。Objective:ToobservetheZhiGanQingChi nesedrugsin preventing andtreatmentofhypercholes terolaemia.Method:Thisexperimentestablishedhyperc holesterolaemiamodelofrabbitbyfeedingheavydosageof cholesterolandobservedthechangesoflipoprotein metabolismofinbloodandliver,itfoundouttheeffectof ZhiGanQingChinesedrugsinpreventingofhypercholes terolaemiacomparingwiththeLovastatine.Result:(1)The Chinesedrugsmarkedlyloweredtotalcholesterol(TC), low -densitylipoproteincholesterol(LDL -C),TC/ HDL -Crate(P<0.01orP<0.05),andmarkedlylow eredactivityoftrans -aminaseinserum(P<0.01).(2) TheChinesedrugsmarkedlyloweredTC,triglicerid(TG), LDL -Cinliver.Conclusion:TheChinesedrugslowered lipidinserum,promotedmetabolismoflipidinliverand protectedthefunctionofliver.

关 键 词：脂肝清 高胆固醇血症 脂蛋白 中药治疗 

分 类 号：R285.5[医药卫生—中药学] R259.892[医药卫生—中医学]