由心率与血压变异性估计民航飞行人员的心血管年龄  

Estimating Cardiovascular Age of Civil Flying Personnel by Means of Heart Rate and Blood Pressure Variability Analysis

作　　者：牛有国[1] 闫永斌 张立藩[3] 张玉海[4] 王守岩[3] 徐秀艳 苏菊侠 

机构地区：[1]第四军医大学航空航天生理学教研室；航空航天临床医学教研室 [2]民航西北管理局飞行标准处, [3]第四军医大学航空航天生理学教研室,西安710068 [4]军队卫生统计学教研室,

出　　处：《航天医学与医学工程》2001年第3期177-181,共5页Space Medicine & Medical Engineering

摘　　要：目的研究由心率与血压变异性估计民航飞行人员心血管年龄的方法 ,并探讨其在心血管疾病防治中的意义。方法先对 89名健康民航飞行人员的心率变异性 (HRV)与血压变异性 (BPV)的谱分析及压力反射敏感性 (BRS)数据进行主成分分析 ,再利用多重回归分析得出心血管年龄的估计方程。结果1 7个HRV、BPV与BRS原指标所蕴含的有关心血管自主神经调节功能状态的信息可由 7个主成分来反映 ,且原始指标变量的第 2与第 4主成分 (PC2 orig,PC4orig)及导出指标变量的第 2主成分 (PC2 deri)分别与实际年龄呈负相关关系 (P <0 .0 5) ,而原始指标变量的第 3主成分 (PC3orig)则与实际年龄呈正相关关系 (P <0 .0 1 ) ;根据估计方程得到的心血管年龄与实际年龄有较好的相关性 (r =0 .73,P <0 .0 1 )。结论由HRV与BPV分析估计得出的心血管年龄可综合反映健康飞行人员心血管自主神经调节功能随年龄的生理性变化 。Objective To estimate the cardiovascular age of civil flying personnel by means of heart rate and blood pressure variability analysis and to evaluate its significance in aviation medicine. Method First, heart rate variability(HRV), blood pressure variability(BPV) and spontaneous baroreflex sensitivity(BRS) were analyzed among 89 healthy civil flying personnel by using conventional AR spectral analysis and sequence method respectively. Then, principal component analysis was conducted over original and derived variables of HRV and BPV spectral and BRS data. Finally, by the use of multiple regression in which the chronological age acted as the dependent variable and the components significantly related to age were used as the regressors, the equation for estimating the cardiovascular age was established. Result Only seven principal components can exactly reflect the same information of autonomic regulatory function which was embodied in the 17 variables of HRV and BPV spectral and BRS parameters. Among the seven principal components, the PC2 orig , PC4 orig and PC2 deri were negatively correlated with the chronological age(P<0.05), whereas the PC3 orig was positively correlated with the chronological age(P<0.01). The cardiovascular age derived from the equation was significantly correlated with the chronological age of the civil flying personnel (r=0.73,P<0.01). Conclusion The cardiovascular age estimated by means of a multi variate analysis of HRV , BPV and BRS can be treated as a comprehensive indicator reflecting the age dependency of autonomic regulatory function of cardiovascular system in healthy civil flying personnel, and its interpretation and significance in application are surely worthy of further and fully dedicated efforts.

关 键 词：飞行员 心率变异性 血压变异性 压力反射敏感度 年龄 

分 类 号：R856.5[医药卫生—航空、航天与航海医学] R331.1[医药卫生—临床医学]