胸腔内注入尿激酶治疗有小房形成的胸腔积液  

Intrapleural urokinase in the treaatment of loculated pleural effusions

作　　者：张新高[1] 刘冬媛[1] 李素英[1] 黎联[1] 邓治平[1] 李大才[1] 赵烈炎 

机构地区：[1]四川省自贡市第一人民医院,自贡643000

出　　处：《中国防痨杂志》2001年第6期376-378,共3页Chinese Journal of Antituberculosis

基　　金：四川省卫生厅科学基金 ( 19980 5 9)

摘　　要：目的　探讨尿激酶对有小房形成的胸腔积液的治疗作用。方法　在病因治疗同时 ,对 6 7例有小房形成的胸腔积液随机分 3组 ,其中 2 5例胸腔内注入尿激酶 10～ 2 0万U +NS 10 0ml ,2 2例胸腔内注入糜蛋白酶 10～ 15万U +NS 10 0ml,2 0例胸腔内注入NS 10 0ml作对照。结果　用药后 ,分隔小房的溶解尿激酶组优于糜蛋白酶组 ,统计学上具有显著性差异 (P <0 .0 5 )。引流量尿激酶组优于糜蛋白酶组 ,二组比较有非常显著性差异 (P <0 .0 1)。生理盐水对分隔小房 ,引流量均无影响。Objective To explore the role of intrapeural injection of urokinase for patients with loculated pleural effusions.Methods 67 patients with loculated pleural effusions were dirided into 3 groups randomly,urokinase or chymotrypsin plus NS 100ml were injected 100?000～200?000U/time respictively into the pleural cavity of 25 and 22 patients with loculated pleural effusions,while NS 100ml was injected into the pleural cavity of 20 patients,as the control group.Results After urokinase or chymotrypsin has been used to dissolve the loculi,the therapeutic effects of UK group were better than chymotrypsin group ( P<0.05 ).As comparing the drainage volumes of fluid,UK group was significantly better than chymotrypsin group ( P<0.01 ),NS was no useless to separated loculi and drainage vulumes of fluid.Conclusion Intrapleural injection of UK or chymotrypsin was the effective and safe method for the treatment of loculated pleural effusions.

关 键 词：尿激酶 胸腔积液 小房 B超检查 

分 类 号：R561.3[医药卫生—呼吸系统]