原发性高血压患者红细胞[Ca^(2+)]i浓度变化及影响因素  

Changes and Effective Factors in Erythrocytes [Ca^(2+)]i Concentration in Primary Hypertension Patients

作　　者：苗丽娜[1] 王萃武[2] 

机构地区：[1]福建省第二人民医院内科,福州350003 [2]福建中医学院生理学教研室,福州35000

出　　处：《福建医科大学学报》2001年第4期351-353,共3页Journal of Fujian Medical University

摘　　要：目的　观察原发性高血压患者红细胞 [Ca2 + ]i,多巴胺 β羟化酶及 ATP含量变化并分析其结果。　方法　测定 35例高血压患者的红细胞 [Ca2 + ]i、ATP、血清多巴胺 β羟化酶活性、血糖及血浆胰岛素含量 ,并以 30例健康成年人为对照。　结果　高血压患者的红细胞 [Ca2 + ]i、ATP、多巴胺 β羟化酶均明显高于对照组 (P<0 .0 5 ,P<0 .0 1) ,但血糖与胰岛素未见明显变化。　结论　高血压患者血清多巴胺 β羟化酶活性增强伴随 ATP与 [Ca2 +Objective\ To observe the concentration changes in erythrocytes [Ca\+\{2+\}]i, ATP, and dopamine beta\|hydroxylase activity in patients of primary hypertension.\ Methods\ To measure the levels of erythrocytes [Ca\+\{2+\}], ATP, plasma insulin and serum dopamine beta\|hydroxylase activity in 35 primary hypertension patients and 30 healthy adults as control.\ Resuls\ The levels of erythrocytes [Ca\+\{2+\}], ATP, and dopamine beta\|hydroxylase activity in hypertension were significant higher than those of the control(P<0.05～0.01).\ But the contents of blood glucose and insulin remained unchanged.\ \{Conclusion\}\ The increased serum dopamine beta\|hydroxylase activity associated with increased ATP and [Ca\+\{2+\}]i in hypertension may be the result of sympathetic nervous system hyperfunction.

关 键 词：高血压 红细胞 多巴胺Β羟化酶 腺苷三磷酸 CA^2+转运 ATP酶 

分 类 号：R544.1[医药卫生—心血管疾病]