UV法测定盐酸二甲双胍肠溶片的释放度和含量  

Determination of metformin hydrochloride enteric-coated tablets by UV

作　　者：封淑华[1] 王丽萍[1] 王俊峰 刘红莉[1] 刘丽芳[3] 马庆[3] 

机构地区：[1]河北省药品检验所,石家庄050011 [2]河北天成药业集团,沧州061000 [3]河北医科大学药学院

出　　处：《中国现代应用药学》2001年第6期463-465,共3页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的 :建立盐酸二甲双胍肠溶片的质量标准。方法 :采用 UV法测定盐酸二甲双胍肠溶片在酸及缓冲液中的释放度及含量。结果 :在选定的波长处 ,辅料及肠溶衣对测定无干扰 ,释放度平均回收率 99.0 % ,含量平均回收率 99.9%。结论 :测定方法简便 ,结果可靠 。OBJECTIVE: Estabilish a method for the quality control of metformin hydrochloride enteric coated tablets. METHOD: The rate of release and content of metformin hydrochloride enteric coated tablets were determinated by UV. RESULTS: The excipient is not interference. The recovery of release is 99.0%, the recovery of content is 99.9%. CONCLUSION:The method is simple and resultes are reliable. It can be used for the quality control.

关 键 词：盐酸二甲双胍肠溶片 释放度 紫外分光光度法 药物含量测定 降血糖药 UV法 

分 类 号：R977.15[医药卫生—药品] R927.2[医药卫生—药学]