壳聚糖-恶丙嗪缓释片的研制  

Preparation of Chitosan-oxaprozin Sustained Release Tablets

作　　者：刘祖雄[1] 李晓东[1] 汤韧[1] 盛莉[1] 

机构地区：[1]广州军区式汉总医院,武汉市430070

出　　处：《中国药房》2001年第9期532-533,共2页China Pharmacy

摘　　要：目的：研究壳聚糖－恶丙嗪缓释片的制备、质量标准，并考察体外释药性能。方法：采用紫外分光光度法测定主药恶丙嗪的含量。结果：线性范围为２．５～１５．０ｕｇ／ｍｌ，平均回收率为９９．７９％，ＲＳＤ为０．３８％。结论：该制剂制备工艺简单，值得临床推广应用。OBJECTIVE: To study the preparation and quality standard of chitosan-oxaprozin sustained release tablets, and observe the rule of in vitro release of oxaprozin. METHODS:The content of oxaprozin in the tablets was determined by UV - spectrophotometry. RESULTS:The linear range was 2. 5- 15. 0ug/ml. The average recovery was 99. 79% with a RSD of 0. 38%. CONCLUSION: The preparation process of chitosan-oxaprozin sustained release tablet is simple. It is worth expanding the app- lication in clinical practice.

关 键 词：壳聚糖 恶丙嗪 缓释片 质量控制 制备 

分 类 号：R944.9[医药卫生—药剂学] R927.11[医药卫生—药学]