中药复方对去卵巢大鼠骨转换生化指标的影响  

Effects of a Herbal Formula MG-1 on Biochemical Markers of Bone Turnover in Ovariectomized Rats

作　　者：谢金华[1] 张晓晖[2] 陈小华[1] 李小侬[1] W.Kent 冯新送[1] 徐敏[3] 

机构地区：[1]广州中医药大学,广州510405 [2]澳大利亚西澳大学 [3]香港中文大学

出　　处：《中药新药与临床药理》2001年第6期417-420,共4页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：本研究为中澳政府间合作项目 (1997-C12 )的部分研究工作 ;广州市科委项目基金;广东省科委项目基金;西澳大学医学奖学金资助

摘　　要：[目的 ]探讨自拟中药复方防治雌激素缺乏引起骨丢失的药效机理。 [方法 ]随机将 1 0月龄雌性SD大鼠分为 3组 :去卵巢组 (OVX)、去卵巢后加中药治疗组 (OVX -M)及去卵巢后加雌激素治疗组 (OVX -E) ;分别于术前和术后第 1、 4、 8和 1 2周对尿吡啶交联 /肌酐比率 (Pyd/Cr)、尿脱氧吡啶交联 /肌酐比率(Dpd/Cr)和血浆碱性磷酸酶 (ALP)含量进行动态观测。 [结果 ]与术前相比OVX组尿Pyd/Cr、Dpd/Cr及血ALP术后各时点平均升高 93%、 1 80 %和 5 9% (P <0 .0 5 ) ;而OVX -M组仅平均升高 39%、 1 0 2 %和 1 9% ;两组变化差异显著 (P <0 .0 5 )。 [结论 ]实验提示自拟中药复方与雌激素替代疗法相似 ,可通过抑制骨转换减少雌激素缺乏引起的骨丢失。To investigate the effect of a Chinese herbal formula, MG-1, on estrogen deficiency bone loss and to study its mechanism. Ten-month old female rats were randomly allocated to three groups: ovariectomized (OVX), OVX treated with MG-1 decoction (OVX-M) and OVX treated with estrogen injection (OVX-E). The urinary pyridinoline creatinine ratio (Pyd/Cr), deoxypyridinoline creatinine ratio (Dpd/Cr), and plasma alkaline phosphatase (ALP) were determined at the baseline, 1, 4, 8 and 12 postoperative weeks. An average increase of 93% in Pyd/Cr, 180% in Dpd/Cr and 59% in plasma ALP (P< 0.05 as compared that before operation) appeared in the OVX group after ovariectomy, and 39% in Pyd/Cr, 102% in Dpd/Cr and 19% in ALP in OVX-M group (P< 0.05 as ompared with OVX rats). [Conclusion] Herbal formula MG-1 possesses a similar effect to estrogen replacement on estrogen dependent bone loss by inhibiting the bone turnover.

关 键 词：中药复方MG-1 药理学 尿吡啶交联 肌酐比率 尿脱氧吡啶交联 碱性磷酸酶 去卵巢大鼠 

分 类 号：R285.5[医药卫生—中药学] R271.116[医药卫生—中医学]