盐酸左旋氧氟沙星滴耳液的制备及质量控制  

Preparation and Quality Control of Levofloxacin Hydrochloride Ear Drops

作　　者：龙远秀 苏德芬 

机构地区：[1]重庆市江北区药品检验所,重庆市400020 [2]重庆市江北区第一人民医院,重庆市400020

出　　处：《中国药房》2001年第7期404-405,共2页China Pharmacy

摘　　要：目的 :研制盐酸左旋氧氟沙星滴耳液。方法 :采用紫外分光光度法测定含量。结果 :线性范围为2～10μg/ml,回收方程为A=1.83×10—3+0.07415C ,r=0.9991(n=5) ;该方法测得平均回收率±标准差为 (98.74±0.51) %。结论:该滴耳液抗菌作用强 ,质量稳定 ,紫外分光光度法测定含量方法简便、快速。OBJECTIVE:To prepare levofloxacin hydrochloride ear drops METHODS:The content of levofloxacin hydrochloride was determined with UV-spectrophotometry RESULTS:The linearity range was 2～10μg/ml with a regression equation of A=1 83×10-3+0 07 415C and r=0 9 991(n=5) The average recovery was (98 74±0 51)% CONCLUSION:The UV-spectrophotometry method is simple,rapid and accurate and the preparation is powerful in antibacterial action and stable in quality

关 键 词：盐酸左旋氧沙星 滴耳液 制备 质量控制 

分 类 号：R987[医药卫生—药品] R943[医药卫生—药学]