左旋咪唑所致脑病的CT、MRI表现  

CT and MRI findings of levamisole induced encephalopathy

作　　者：高波[1] 吕翠[2] 马效德[1] 吕文翠[3] 毕研翠[1] 高龙飞[2] 李庆国[1] 

机构地区：[1]山东省莱芜市人民医院放射科,271100 [2]山东省莱芜市人民医院神经内科,271100 [3]山东省莱芜市人民医院门诊部,271100

出　　处：《中华放射学杂志》2001年第12期914-916,共3页Chinese Journal of Radiology

摘　　要：目的　探讨左旋咪唑所致脑病的CT、MRI表现。方法　回顾性分析临床确诊此病的6例病人的CT、MRI资料 ,其中 5例行钆喷替酸葡甲胺 (Gd DTPA)增强扫描 ,4例在MRI检查前行CT检查。结果　MRI表现 :共发现 6 4个病灶 ,主要位于双侧侧脑室周围及皮层下白质内 ,呈多发散在分布 ,大小不等 ;以不规则斑片 (块 )状最多 (36 / 6 4) ,其次为 (类 )圆形或小点状结节灶 ;病变T1WI多呈不均匀低信号 (5 7/ 6 4) ,T2 WI全部呈高信号 ,一般无强化 ;水肿及占位效应轻。液体衰减反转恢复序列(FLAIR)多呈明显高信号。CT表现 :2例表现为双侧侧脑室周围白质内多发散在分布的不规则斑片状低密度影 ;1例表现为双侧豆状核内对称性片状低密度影 ;另外 1例CT表现阴性。结论　CT、MRI对本病的诊断和鉴别诊断具有重要价值 ,MRI比CT具有更高的敏感性和特异性 ,能更好地评价其治疗和预后。Objective To investigate the CT and MRI features of levamisole induced encephalopathy. Methods The CT and MRI features of 6 cases with clinically proven levamisole induced encephalopathy were retrospectively analyzed. Gd-DTPA enhancement examinations were performed in 5 cases. CT examinations were performed in 4 cases before MRI. Results MRI features: Lesions were mainly located in bilateral periventricular and hypophloeodal white matter, scattered as multifocal lesions, and were different in sizes. Most of the lesions presented as irregular plaques (masses), with round/oval or spotty nodules in second. The lesions had low signal intensity on T 1WI and high signal intensity on T 2WI, and commonly without enhancement. Edema and mass effect were slight. CT features: Two cases showed multiple irregular plaque-sheet low density lesions scattered in bilateral periventricular white matter. One showed symmetrical low density in bilateral putamina nuclei. Another one was negative. Conclusion CT and MRI are valuable for the diagnosis and differentiated diagnosis of levamisole induced encephalopathy. MRI has higher sensitivity and specificity than CT does, and can favorably evaluate the treatment and prognosis.

关 键 词：左旋咪唑 药物毒性 脑疾病 体层摄影术 X线计算机 磁共振成像 驱虫药 

分 类 号：R816.1[医药卫生—放射医学]