^(99)Tc^m-HMPAO在大鼠大脑神经细胞内的分布研究  

A study on the location of ^(99)Tc^m-HMPAO in neurons of rat brain

作　　者：李志杰[1] 谭斐[2] 裴著果[1] 张彩霞[1] 

机构地区：[1]中国医科大学第二临床学院核医学科,沈阳110003 [2]中国医科大学第二临床学院神经内科,沈阳110003

出　　处：《中华核医学杂志》2001年第6期353-354,I002,共3页Chinese Journal of Nuclear Medicine

基　　金：辽宁省社会发展基金资助项目 (992 2 50 0 1 )

摘　　要：目的　探讨99Tcm 6甲基丙二胺肟 (HMPAO)在神经细胞内的分布特点。方法　采用脑血流放射自显影方法观察 3只正常大鼠和 11只大脑中动脉栓塞 (MCAO)大鼠光镜与电镜下神经细胞内99Tcm HMPAO银颗粒的分布特点。结果　99Tcm HMPAO主要分布在神经细胞的胞浆及突起中 ,不同细胞对99Tcm HMPAO的摄取不尽相同。MCAO后缺血半暗区99Tcm HMPAO弥漫性分布稀疏 ,梗死区几乎无摄取。结论　99Tcm HMPAO在神经细胞内的滞留可能与浆液内进行的代谢过程有关。Objective To study the location of 99Tcm-HMPAO in neurons. Methods Cerebral blood flow autoradiography was done in 3 normal rats and 11 rats with right middle cerebral artery occlusion(MCAO) and observed with light and electron microscope. Results 99Tcm-HMPAO silver particles were observed in the cytoplasm and processes of normal neurons and the distribution was not even among different neurons. In MCAO rats, the distribution of 99Tcm-HMPAO silver particles showed diffuse decrease in ischemic penumbra and almost disappeared in the infarcted core. Conclusion The retention of 99Tcm-HMPAO in neurons might be correlated with the metabolic process taking place in cytoplasm.

关 键 词：脑栓塞 HMPAO 放射自显影 神经细胞 

分 类 号：R817.1[医药卫生—影像医学与核医学]