2型糖尿病与活动性巨细胞病毒感染关系的探讨  

Study on Relations Between Type 2 Diabetes Mellitus and Active Cytomegalovirus Infection

作　　者：梁浩[1] 陈晖[2] 苏洁寒[1] 梁瑜祯[3] 于志清[3] 邬质彬[1] 黎燕宁[1] 

机构地区：[1]广西医科大学公共卫生学院流行病学教研室,南宁530021 [2]广西南宁市第一人民医院内科 [3]广西医科大学第一附属医院糖尿病中心

出　　处：《中国公共卫生》2001年第12期1085-1086,共2页Chinese Journal of Public Health

基　　金：广西教育厅课题 (项目编号 1 9982 9)

摘　　要：目的　探讨 2型糖尿病与活动性巨细胞病毒 (CMV)感染的关系。方法　应用PCR技术和ELISA法分别检测 47例 2型糖尿病病人血清中CMVDNA和CMV IgM。以CMVDNA(或 )CMV IgM阳性为活动性CMV感染诊断指标。结果　PCR技术和ELISA法检测结果具有高度一致性 (P <0 0 0 1)。 2型糖尿病病人活动性CMV感染率 (5 3 19%)显著高于对照组 (2 1 88%) (P <0 0 1) ,且活动性感染的病人中病程长于 6个月者占 72 %。血糖水平较高的病人活动性CMV感染率与血糖水平较低者比较差异有显著性意义 (P <0 0 5 )。结论　 2型糖尿病病人中存在较高的再发感染 ,这可能与 2型糖尿病发病有关。Objective To find out the relations between type 2 diabetes mellitus and active cytomegalovirus(CMV) infection.Methods HCMV DNA and CMV-IgM in sera from 47 type 2 diabetic patients were respectively detected by polymerase reaction (PCR) and ELISA.Patients with positive CMV DNA and (or) CMV-IgM was diagnosed as active CMV infection.Results There was a high correlation between PCR and ELISA in determining HCMV infection (P<0.001).The active CMV infection rate of type 2 diabetic patients was significantly higher than that of the controls (P<0.01),and 72% patients with active CMV infection had a course of disease more than 6 months.The active CMV infection rate of type 2 diabetic patients with higher blood sugar was much higher than that of those with lower blood sugar (P<0.05).Conclusion There existed a higher re-infection of CMN in type 2 diabetic patients,which was possibly related to the pathogenesis of type 2 diabetes mellitus.

关 键 词：2型糖尿病 人类巨细胞病毒 多聚酶联反应 酶联免疫吸附法 

分 类 号：R587.1[医药卫生—内分泌]