甲型肝炎减毒活疫苗(H_2株)保护效果的研究  

Assessment on Effects of Live-attenuated Hepatitis A Vaccine (H_2 strain)

作　　者：汪萱怡[1] 刘洪斌 徐志一[1] 赵玉良 姚金峰 郭俊杰 多成钢 孟宗达 顾惠心[1] 

机构地区：[1]上海医科大学流行病学教研室,200032 [2]河北省卫生防疫站 [3]河北省阜城县卫生防疫站

出　　处：《中国公共卫生》2001年第12期1087-1088,共2页Chinese Journal of Public Health

基　　金：国家"九五"攻关课题 (基金编号 :96 - 90 6 - 0 1 - 0 1 )

摘　　要：目的　观察国产甲型肝炎减毒活疫苗 (H2 株 )在甲型肝炎流行情况下 ,其保护发病与保护感染效果。方法　在某乡甲肝流行情况下 ,采用病例对照研究方法 ,调查病例组与对照组甲肝疫苗免疫史 ,估计疫苗保护发病效果 ;选择该乡发病率较高的 13个村小学学生 ,进行血清学及甲肝疫苗接种史调查 ,计算疫苗保护感染效果。结果　甲肝减毒活疫苗保护率为98 1%,95 %可信限下限为 83 5 %。隐性感染率在接种组与未接种组分别为 10 2 3%和 11 5 9%,两者无统计学差异。结论　国产甲型肝炎减毒活疫苗 (H2 株 )具有很好的保护发病效果 ,可以同国外灭活疫苗相媲美 ,其保护感染效果不及保护发病效果。Objective To assess the effects of domestic live-attenuated hepatitis A vaccine in an epidemic.Methods A case-control study of live-attenuated hepatitis A vaccine was conducted in a village with an epidemic of HA.All vaccination histories were obtained from pre-existing immunization records.The effect was estimated.All subjects from 13 primary schools with high morbidity were bled to study the effect on preventing HAV.Results The protective rate of the vaccine was 98.1%,the 95% low confidence interval is 83.5%.The subclinic infection rate of vaccined group and unvaccined group were 10.23% and 11.59% respectively.There had no statistical difference between two groups.Conclusion Domestic live-attenuated hepatitis A vaccine had good protective function.The effects were equal to foreign inactivated vaccine.But the effect to prevent HAV infection was not good.

关 键 词：甲型肝炎 免疫学 H2株 甲肝疫苗 

分 类 号：R512.61[医药卫生—内科学]