鸡蛋黄抗体IgY的急、慢性毒性实验  

Tests of acute and chronic toxicity of egg-yolk IgY

作　　者：江千舟[1] 樊明文[1] 李宇红[1] 边专[1] 黄欣[1] 

机构地区：[1]武汉大学口腔医学院,湖北武汉430079

出　　处：《牙体牙髓牙周病学杂志》2001年第6期389-391,共3页Chinese Journal of Conservative Dentistry

基　　金：湖北省科委科技攻关项目 ( 982P16 0 2 )

摘　　要：目的 :通过观察实验动物使用鸡蛋黄抗体IgY后的急、慢性毒性反应 ,评估鸡蛋黄抗体IgY的安全性。方法 :昆明小鼠 ,雌雄各 10只 ,鸡蛋黄抗体IgY喷漱液经口灌胃连续 1周 ,并记录动物中毒症状及死亡情况。Wistar大鼠 80只 ,分为受试物低、中、高剂量组 ,经口灌胃 30d后 ,观察大鼠血液生化指标及脏器变化。结果 :1周内小鼠未见明显中毒症状和死亡发生。 30d后大鼠临床检查、血液、生化、脏器组织病理学等项目测定均无异常。结论 :按急性毒性分级 ,IgY属无毒级类物质 ,且无慢性毒性表现。AIM: To evaluate the security of egg-yolk IgY by acute toxicity test and thirty days feeding test. METHODS: Test 1: IgY in high dose were gaven to 20 Kunming mice. After one week, the death and symptom of toxicity were observed. Test 2: IgY in different concentration were continuously gaven to 80 Wistar rats for 30d, after 30 days the indications of the rats were tested. RESULTS: All the results in these two tests were negative. CONCLUSION: Egg-yolk IgY has no toxicity to the body.

关 键 词：鸡蛋黄抗体 急性毒性 慢性毒性 IGY 

分 类 号：R977[医药卫生—药品] R965.3[医药卫生—药学]