北五味子粗多糖抗衰老作用的实验研究  

The experimental study of CPSC on anti-aging

作　　者：孙文娟[1] 吕文伟[1] 于晓凤[1] 吕忠智[1] 王胜[2] 

机构地区：[1]吉林大学基础医学院药理教研室，吉林 长春 130021 [2]吉林大学第一医院

出　　处：《中国老年学杂志》2001年第6期454-455,共2页Chinese Journal of Gerontology

摘　　要：目的　观察北五味子粗多糖的抗衰老作用。方法　北五味子粗多糖按 1 0 0、2 0 0、40 0 mg/kg连续灌胃 3～ 7d,观察小鼠的存活时间 ,连续游泳时间和免疫器官重量试验。大鼠连续灌胃 2 0 d,测血清 LPO含量和 SOD活性。结果　北五味子粗多糖能明显提高小鼠耐氧及抗疲劳能力 ,增加正常小鼠免疫器官重量 ,并明显增强小鼠网状内皮系统的吞噬功能。可明显降低老年大鼠血清过氧化脂质 (L PO)含量 ,提高超氧化物歧化酶(SOD)活性。? Objective To evaluate the effect of CPSC on anti aging. Methods After the mice were treated p.o with CPSC 100?200?400 mg/kg for 3～7 days continually, the survival time?swimming time and weight of immune organ were investigated; after the aged rats were treated for 20 days, the content of serum LPO and the activity of SOD were determined. Results CPSC could obviously enhance the anti fatigue and the hypoxia tolerance ability, increase the weight of immune organ and improve the immune macrophage function in the mice. In addition, CPSC significantly decreased the content of serum LPO and increase the activity of SOD in the aged rats. Conclusion Our results indicated that CPSC has anti aging effect.

关 键 词：北五味子粗多糖 抗衰老 血清过氧化脂质 超氧化物岐化酶 网状内皮系统 机体免疫功能 

分 类 号：R285.5[医药卫生—中药学] R－332[医药卫生—中医学]