灯盏花素注射液稳定性研究  

An Investigation of the Chemical Stability of Dengzhanhuasu Injection

作　　者：李水清[1] 阎芳[1] 

机构地区：[1]山东省临沂市人民医院,276003

出　　处：《医药导报》2001年第11期712-712,共1页Herald of Medicine

摘　　要：目的 :研究灯盏花素注射液的化学稳定性 ,为保证药效提供依据。方法 :采用初均速法 ,分别在 40 ,5 0 ,6 0 ,70 ,80 ,90℃ (± 1℃ )下 ,恒温加热不同时间 ,用紫外分光光度计测定灯盏花素注射液各样品的吸收度。结果 :相关系数r为 0 .990 4,说明lgVo与 1 T的线性关系良好 ,符合一级动力学公式。结论 :灯盏花素注射液的热解反应活化能为88.93kJ·mol 1 ,以Arrhenius指数规律推算τ2 0℃0 .9　贮存期约 6 .5a ,τ2 5℃0 .9　贮存期约 3 .5a。Objective:To study the chemical stability of Dengzhanhuasu injection so as to provide information regarding the effectiveness of the injection. Methods:The constant heating method was used to heat the sample for various length of time at 40℃, 50℃, 60℃, 70℃, 80℃, and 90℃(±1℃), and ultraviolet spectrophotometry was used for determination of UV absorbance by various samples. Results:A good linear relationship existed between LgVo and 1/T with a correlation coefficient of 0.990 4. Conclusion: The pyrolysis activity energy of Dengzhanhuasu injection is 88.93 KJ/mol. Thus a storage time of 6.5a for τ 20℃ 0.9 and 3.5 a for τ 25℃ 0.9 can be calculated.

关 键 词：灯盏花素注射液 贮存期 药物稳定性 

分 类 号：R282.710.5[医药卫生—中药学]