l-对甲苯磺酰乳酸乙酯合成中产率分析方法的研究  

ON THE METHOD OF DETERMINATION OF RATE OF PRODUCTION IN THE SYNTHESIS OF l-ETHYL-p-TOLUENE SULPHONYL LACTATE

作　　者：郝素娥[1] 金婵[1] 李丽[1] 

机构地区：[1]哈尔滨工业大学应用化学系,哈尔滨150001

出　　处：《理化检验（化学分册）》2001年第12期551-552,555,共3页Physical Testing and Chemical Analysis(Part B:Chemical Analysis)

基　　金：黑龙江省自然科学基金资助项目 ( 980 741-0 2 7)

摘　　要：报道了实验室可行、工业生产实用的l 对甲苯磺酰乳酸乙酯产率的分析方法 ,采用K2 CrO4 K2 Cr2 O7混合指示剂 ,其最佳配比为K2 CrO4 ∶K2 Cr2 O7=6∶1(质量比 ) ,体系的最佳 pH为5 .8,测得l 乳酸乙酯与对甲苯碘酰氯反应制备的l 对甲苯磺酰乳酸乙酯的产率为 94 .0 %The synthesis of l ethyl p toluene sulphonyl lactate is carried out industrially or in laboratory through the reaction of l ethyl lactate and p toluenesulphonyl chloride. It is proposed that by determination of the Cl - in the water phase, the rate of production of the compound mentioned above can be deducted. The determination of chloride ion is done by the argentometric titration. A mixed indicator composed of K 2CrO 4 and K 2Cr 2O 7, having a ratio 6∶1 by mass is recommended. The acidity of the solution during titration should be adjusted to pH 5.8. The rate of production obtained by this method is 94.0%.

关 键 词：l-乳酸乙酯 l-对甲苯磺酰乳酸乙酯 银盐滴定法 混合指示剂 K2CrO4-K2Cr2o7 

分 类 号：TQ247.52[化学工程—有机化工] O625.52[理学—有机化学]