妊娠合并系统性红斑狼疮患者血清白细胞介素6、8检测的临床意义  

The changes of serum levels of interleukin-6 and interleukin-8 in pregnant women with systemic lupus erythematosus

作　　者：苏彧[1] 洪素英[1] 张羽[1] 孙赟[1] 

机构地区：[1]上海第二医科大学附属仁济医院妇产科,200001

出　　处：《中华妇产科杂志》2001年第11期660-662,共3页Chinese Journal of Obstetrics and Gynecology

摘　　要：目的　探讨妊娠合并系统性红斑狼疮 (SLE)稳定期的患者血清中白细胞介素 6 (IL 6 )、白细胞介素 8(IL 8)水平变化的临床意义。方法　采用固相酶联免疫反应法 ,对 14例SLE稳定期 (仅服用小剂量强的松 )患者 (SLE组 ) ,12例正常孕妇 (正常孕妇组 )和 12例正常未孕妇女 (正常未孕组 )的血清IL 6、IL 8水平进行检测。结果　SLE组患者的血清IL 6、IL 8水平分别为 (2 0 31± 5 70 )ng/L和 (4 8 80± 9 17)ng/L ;显著高于正常孕妇组 [IL 6、IL 8水平分别为 (8 40± 2 49)ng/L和 (2 1 15±5 2 1)ng/L ,P <0 0 1]和正常未孕组 [IL 6、IL 8水平分别为 (6 14± 0 86 )ng/L和 (17 71± 4 43)ng/L ,P<0 0 1]。而正常孕妇组与正常未孕组之间比较 ,差异无显著性 (P >0 0 5 )。结论　妊娠合并SLE患者的血清IL 6、IL 8水平变化 ,可能对判断病情进展及预后有重要作用。Objective To assess the changes of serum levels of interleukin-6(IL-6) and interleukin-8 (IL-8) in pregnant women with stationary phase systemic lupus erythematosus (SLE). Methods Enzyme-linked immunosorbent assay (ELISA) was used to measure serum IL-6 and IL-8 from 14 pregnant women with stationary phase SLE (SLE group), 12 normal pregnant women (normal pregnant group) and 12 normal non-pregnant women (group normal non-pregnant). The later two groups are set as controls. Results The IL-6, IL-8 levels in group SLE patients are (20.31±5.70) ng/L and (48.80±9.17) ng/L, significantly higher than those in normal pregnant group [IL-6, IL-8 levels are (8.40±2.49) ng/L and (21.15±5.21) ng/L, respectively, P <0.01)] and normal non-pregnant group [IL-6, IL-8 levels are (6.14±0.86) ng/L and (17.71±4.43) ng/L, respectively, P <0.01]. However, there′s no significant difference between the normal pregnant group and normal non-pregnant group ( P >0.05). Conclusion Serum levels of IL-6, IL-8 may be helpful to monitor the progress of SLE during pregnancy.

关 键 词：系统性红斑狼疮 白细胞介素-6 白细胞介素-8 妊娠并发症 预后 自身免疫性疾病 

分 类 号：R714.25[医药卫生—妇产科学] R593.241[医药卫生—临床医学]