达曲班对体外培养心肌细胞缺氧缺糖性损伤的保护作用  

Effects of Daltroban on Cultured Neonatal Rat Heart Cells in vitro

作　　者：郭秀丽[1] 张世玲[1] 

机构地区：[1]山东大学药学院药理教研室,山东济南250012

出　　处：《中国医药工业杂志》2001年第10期460-462,共3页Chinese Journal of Pharmaceuticals

基　　金：山东省自然科学基金资助课题 (编号 94C12 2 8)

摘　　要：研究了达曲班对体外培养心肌细胞缺氧缺糖性损伤的保护作用。达曲班 170、340 μmol/ L 能显著加快缺氧缺糖后心肌细胞的搏动频率 ,提高心肌细胞的活力 ;达曲班 340 μm ol/ L 能显著降低培养液中乳酸脱氢酶 (L DH)的活性 。Protective effects of daltroban on cultured neonatal rat heart cells were studied. Heart cells were cultured under oxygen and glucose deprivation. After oxygen and glucose deprivation, dose 170 and 340 μmol/L of daltroban accelerated the pulsatile frequency and enhanced the viabilities of heart cells significantly; dose 340 μmol/L of daltroban decreased the activity of LDH in cultured liquid and improved the morphology of heart cells.

关 键 词：达曲班 心肌细胞 缺氧缺糖 LDH 

分 类 号：R972.3[医药卫生—药品] R965.1[医药卫生—药学]