格华止对2型糖尿病患者胰岛素抵抗的影响  

Effects of Metformin on Insulin Resistance in Type 2 Diabetes Mellitus Patients

作　　者：吴国亭[1] 韩玉麒[1] 王吉影[1] 李文君[1] 顾耀[1] 石莹[1] 

机构地区：[1]同济大学附属铁路医院内分泌科,上海200072

出　　处：《同济大学学报（医学版）》2001年第6期31-32,35,共3页Journal of Tongji University(Medical Science)

摘　　要：目的　探讨二甲双胍 (商品名 :格华止 )对 2型糖尿病患者胰岛素抵抗的影响。方法　 12 0例 2型糖尿病患者随机分为两组 ,治疗组 6 0例 2型糖尿病患者口服格华止治疗 ,每次 0 .5 g ,一日 2次 ;安慰剂组 6 0例 2型糖尿病患者口服安慰剂 ,疗程为 2 4周。结果　 (1)第 4周时 ,格华止对降低患者的空腹血糖及餐后 2h血糖 ,糖化血红蛋白有明显疗效 ;(2 ) 2 4周后 ,格华止使患者体重、血清胰岛素水平下降 ,红细胞胰岛素受体、膜流动性和胰岛素敏感指数增加。结论　格华止能提高 2型糖尿病患者的胰岛素敏感性。Objective To investigate the effects of Metformin on insulin resistance in type 2 diabetes mellitus (DM) patients.Methods 120 type 2 DM patients were divided into two groups.In treatment group,60 type 2 DM patients were treated with Metformin;while in placebo group,60 type 2 DM patients were treated with placebo.They all were treated for 24 weeks.Results Metformin had significant effect on lowering the fasting and postprandial 2?hour blood glucose and glycosylated haemoglobins (HbAIc) after 4 weeks.Body weight lowered,and the insulin sensitivity index,binding capacity of erythrocyte insulin receptor and erythrocyte membrane fluidity increased significantly after 24 weeks.Conclusion Metformin can improve insulin sensitivity in type 2 DM patients.

关 键 词：糖尿病 2型 胰岛素 二甲双胍 

分 类 号：R977.15[医药卫生—药品] R969[医药卫生—药学]