丁胺卡那霉素对新生儿耳毒性的研究  

Study of Ototoxicity in Newborn With Amikacin.

作　　者：卢光进[1] 刘皖君[2] 

机构地区：[1]深圳市宝安妇幼保健院,广东深圳518133 [2]同济医科大学附属同济医院,湖北武汉430030

出　　处：《中国儿童保健杂志》2001年第4期221-222,共2页Chinese Journal of Child Health Care

摘　　要：【目的】　探讨丁胺卡那霉素对新生儿的耳毒性。　【方法】　选取疑有感染性疾病而需用抗生素的足月新生儿 34例 ,根据丁胺卡那霉素用药剂量及方法分为 4组 ,另设 6例作对照。　【结果】　全部对象听觉脑干诱发反应 (ABR)波及波间潜伏时均值正常 ,每天 1次用药组 2 1例中有 3例异常 ,而每天 2次用药组 13例中有 5例异常 ,其差别有极显著意义。随访 4例异常者 ,其中 3例恢复正常。　【结论】　 34例中有 8例ABR异常 ,每天 2次用药者的异常率是每天 1次用药的 3倍。提示使用丁胺卡那霉素治疗 <7天 ,每天 1次用药 ,发生听力损害的可能小 ,即使发生 。Objective To evaluate the changes of ototoxicity in newborn children given Amikacin therapy. Methods It was divided into four groups for study that the 34 neonates suspected infection required Amikacin therapy,and 6 for control group. Results All wave latency average values of the subjects were normal.The incidenceof auditory brainstem response(ABR) abnormality of those taken Amikacin twice daily was much higher than those with once daily,it was significant difference( P <0.01).Auditory toxicity was detected in 3 of the twenty one Amikacin treated patients once daily and in 5 of the thirteen patients twice daily.4 case werefollowed up after discharge. Conclusions 8 of 34 cases had ABR abnormality.Ototoxicity were positively related to the usage of Amikacin.The incidence of ABR abnormality of those with twice daily is 3 times more than those with once daily.The results indicate that the risk is small,when the therapeutic couse of Amikacinwas <7 days, that clinical significant hearing impairment will be development, even ABR abnormality presented,it will recover soon.

关 键 词：丁胺卡那霉素 耳毒性 新生儿 

分 类 号：R764.431[医药卫生—耳鼻咽喉科] R978.12[医药卫生—临床医学]