美蓝预防和减少腹部手术后腹膜粘连的研究  

REDUCTION AND PREVENTION OF HUMAN SURGERY-INDUCED PERITONEAL ADHESIONS BY METHYLENE BLUE

作　　者：李小荣[1] 周军[1] 李小刚[1] 杨连粤[1] 

机构地区：[1]中南大学湘雅医院外科,长沙410008

出　　处：《中国现代医学杂志》2001年第10期9-10,共2页China Journal of Modern Medicine

基　　金：湖南省医药卫生科学技术基金资助项目编号为 9910

摘　　要：探讨美蓝在临床上是否具有预防和减少腹部手术后腹膜粘连的作用及可能的机制。方法 :32例急性弥漫性腹膜炎及粘连性肠梗阻手术病人被随机分为两组 :美蓝组及对照组。观察其术后恢复情况及血清肿瘤坏死因子α(TNFα)水平、丙二醛 (MDA)含量及血红细胞超氧化物歧化酶 (SOD)活力的变化。结果 :美蓝组病人术后恢复优于对照组 ,术后血清MDA含量升高较对照组显著降低 ,血红细胞SOD活力的下降不如对照组 ,血清TNF水平明显低于对照组。结论 :美蓝可以预防和减少腹部手术后腹膜粘连 ,其作用的机制可能与美蓝抑制氧自由基的产生 ,降低TNFα水平 ,使腹膜损伤减轻有关。Objective:To study reduction and prevention of human surgery-induced peritoneal adhesions by methylene blue and its mechanisms.Methods:32 patients with acute peritonitis or intestinal obstruction were randomized into two groups:methylene blue group and control group.Blood MDA,TNFα and SOD were investigated.Results:The recuperation in methylene blue group is better than control group,The level of serum MDA and TNFα were significantly suppressed in methylene blue group,Blood SOD activities were markedly decreased in control group.Conclusions:Methylene blue may reduce and prevent human surgery-induced peritoneal adhesions.

关 键 词：美蓝 腹膜粘连 肿瘤坏死因子 预防 术后 机制 

分 类 号：R656.4[医药卫生—外科学]