大鼠心肌梗塞后梗塞区胆碱能神经支配的变化  

CHANGES OF CHOLINERGIC INNERVATION IN MYOCARDIUM OF RAT AFTER MYOCARDIAL INFARCTION

作　　者：徐嘉惠[1] 薛红杰[1] 赵玲辉[2] 聂春生[2] 张云芳[2] 刘宇 

机构地区：[1]哈尔滨医科大学第一临床医学院第二住院部,哈尔滨150001 [2]哈尔滨医科大学解剖学教研室 [3]黑龙江华兴制药股份有限公司

出　　处：《解剖学杂志》2001年第6期560-564,共5页Chinese Journal of Anatomy

摘　　要：目的 :探讨大鼠心肌梗塞区胆碱能神经支配的变化。方法 :实验用 2 0只大鼠 ,以组织化学Karnovsky Roots法显示胆碱能神经纤维 ,应用多功能图像分析仪测定梗塞区胆碱能神经纤维密度。结果 :大鼠心肌梗塞后 4天 ,梗塞区胆碱能神经纤维密度显著下降 ;梗塞后 1 4天 ,梗塞区胆碱能神经纤维完全消失 ;梗塞后 1 2 0天 ,心肌梗塞区的部分区域出现胆碱能神经纤维。结论 :大鼠心肌梗塞后 1 4天 ,梗塞区发生完全的去胆碱能神经支配 ,1 2 0天后部分区域出现胆碱能神经再支配。Objective:To study the changes of cholinergic innervation in myocardial infarct area in rats.Methods:Cholinergic fibers were showed by the methods of histochemical Karnovsky Roots and the density of cholinergic fibers in myocardial infarct area was measured by medical image analysis processing system in 20 rats.Results:The density of cholinergic fibers decreased in 4 d after myocardial infarction,the fibers disappeared in 14 d,but appeared again in some parts of myocardial infarct area in 120 d.Conclusion:Denervation of cholinergic fibers occurs in 14 d and reinnervation appears 120 d after myocardial infarction in rats.

关 键 词：心肌梗塞 胆碱能神经 去神经支配 神经再支配 

分 类 号：R542.22[医药卫生—心血管疾病]