脐血对骨折愈合影响的实验研究  

The influence of the umbilical cord blood on fracture healing:an experimental study

作　　者：张会生[1] 何强[1] 李达[1] 李安民[1] 李自强[1] 朱森树[1] 郝青虎[1] 

机构地区：[1]中国人民解放军第二五一医院,河北张家口075000

出　　处：《中国骨伤》2001年第11期673-674,共2页China Journal of Orthopaedics and Traumatology

摘　　要：目的　探讨同种及异种脐血是否有促进骨折愈合的作用。方法　 72只新西兰大耳兔在实验性胫骨横断骨折固定后 ,随机被分为兔脐血组、人脐血组、无脐血组及血肿组 ,每组 18只。前三组均于骨折部位置引流管 ,密闭切口 ,术后行闭式引流大约 2 4小时 ,再经皮于骨折处分别注入兔脐血、人脐血及生理盐水 3ml,血肿组不引流也不注入任何试剂。分期抽血做免疫学检查 ,包括IgG和SIL 2R ,取实验胫骨摄X线片及做光镜、电镜检查。结果　血肿组较无脐血及血肿组骨折愈合时间短 1周 ,两脐血组间无明显差异 ,骨愈合时间比上述二组短 1～ 2周左右。免疫学检查术后各组间未见显著性差异。结论　同种及异种脐血有促进骨折愈合作用。局部注射脐血无异常免疫反应。Objective*'To explore the effect of homogeneous and heterogenous umbilical cord blood on fracture healing Methods*'After establishment of transverse fracture of tibia,72 New Zealand rabbits were divided into four groups:rabbit umbilical cord blood group,human umbilical cord group,no cord blood group and hematoma group,each of 18 rabbits.In the former three groups,drainage tube was placed in fracture sites and closed drainage was perfromed for about 24 hours.The rabbit umbilical cord blood,human umbilical cord and saline of 3ml were injected into fracture points of the three groups respectively.In hematoma group,drainage was not placed and nothing was injected.Immunologic test including IgG and SIL 2R was done and X ray, optical microscope and electron microscope examination of tibia was also carried out.Results*'The fracture healing during of umbilical cord blood groups were 1 week shorter than that of hematoma group and 2 weeks than that of no cord blood group.The fracture healing during of the two umbilical cord blood groups had no obvious difference.The results of immunologic test showed no obvious difference between the four groups.Conclusion*'Homogeneous and heterogenous umbilicus cord blood were effective in promoting fracture healing.There was no abnormal immunologic reaction after injection of umbilical cord blood in local place.

关 键 词：骨折愈合 胎血 免疫学试验 

分 类 号：R683.03[医药卫生—骨科学] R331[医药卫生—外科学]