吗啡对大鼠选择性饮水动机的强化效应  

REINFORCEMENT OF MORPHINE ON SELECTIVE DRINKING MOTIVATION IN RATS

作　　者：谭北平[1] 陈晶[1] 杨晓燕[1] 隋南[1] 

机构地区：[1]中国科学院心理研究所,北京100101

出　　处：《中国药物依赖性杂志》2001年第4期254-257,共4页Chinese Journal of Drug Dependence

基　　金：中科院知识创新工程基金 (KSCX2 -2-03);中科院青年科学家小组基金;国家自然科学基金 (39970256)

摘　　要：目的··:研究吗啡对大鼠选择性饮水行为和动机的影响。方法·· :给大鼠间歇性或连续性地饮用含吗啡的黄连素溶液 ,以大鼠在呈现两种不同溶液时选择吗啡溶液的比率为指标 ,进行测试 ,每3d一次。20d后 ,用高浓度吗啡蔗糖溶液进行干预后再测试。结果·· :大鼠饮用吗啡溶液2周后 ,吗啡溶液选择比率显著升高 ,并与饮用吗啡浓度和饮用程序有关 ;测试前饮用吗啡能降低吗啡溶液选择比率 ,亦存在显著剂量相关。结论··:吗啡可以显著性增加大鼠选择性饮水行为 。Objective:To study the effects of morphine on selective drinking behavior of rats. Method: Berberine-morphine solution(BH-MH) was administered to rats either continuously or intermittently to set up a model. The ratio of morphine selecting (MHSR) in front of BH-MH and water was the index in the test. The rats were tested once every three days for 2 weeks. After 20 days, the morphine-sucrose solution was given before the test to observe the intervention. Result: The MHSR increased significantly 12 hours after BH-MH solution taken. Exposure of morphine before test could decrease the MHSR dose-dependently. Conclusion: Morphine could reinforce significantly the morphine drinking motivation, which was related to drug-taking schedule.

关 键 词：吗啡 成瘾 动机 饮水行为 

分 类 号：R996[医药卫生—毒理学] R595.4[医药卫生—药学]