哮喘患儿诱导痰液中IL-8含量测定的临床意义  

The Clinical Significance of Measurement of IL-8 Level in Induced Sputum of Asthmatic Children

作　　者：程国强[1] 洪建国[1] 李臻[1] 李晓青[1] 王乃礼[1] 

机构地区：[1]上海市第一人民医院儿科,上海200080

出　　处：《上海免疫学杂志》2001年第5期295-297,共3页Shanghai Journal of Immunology

摘　　要：探讨哮喘患儿诱导痰液中IL 8测定的临床意义。采用ELISA法分别测定 4 1例不同时期、不同程度的哮喘患儿和 11例正常儿童诱导痰液中IL 8含量 ,便携式肺功能仪测定肺通气功能。哮喘组患儿诱导痰液中IL 8含量较对照组显著增高 ,P <0 0 5 ;中、重度发作期哮喘患儿诱导痰液IL 8含量较稳定期显著增高 ,P <0 0 5。诱导痰液中IL 8含量与 1s用力呼气容积占预计值百分比 (FEV1 0 % )呈显著负相关。IL 8参与了儿童哮喘的发生和发展 ,诱导痰液中IL 8含量可反映气道炎症的变化 ,可用于儿童哮喘发病机制的研究。To investigate the clinical significance of measuring the IL 8 level in induced sputum of asthmatic children,the concentration of IL 8 in induced sputum of 41 cases with varied severity during different conditions of the patients was measured through ELISA,and the ventilated function of lung was determined through portable spirometer It was found that the level of IL 8 in induced sputum of asthmatic children was higher than those of the controls Among the asthmatic group,the levels of IL 8 in induced sputum were significantly different and those of the asthmatic children significantly correlated with the baseline FEV 1 0% It concludes that the concentration of IL 8 in induced sputum can reflect the changes of airway inflammation,and the measurement of this cytokine can be used as a means to assess the severity of asthma as well as for the guidance of effectiveness in clinical therapy in children

关 键 词：哮喘 儿童 IL-8 痰液 测定 

分 类 号：R725.622.5[医药卫生—儿科]