人类基因组多态数据库Go!Poly及其应用  

Introduction to Go!Poly, a human genome polymorphism database

作　　者：陈炜[1] 张戈[1] 张思仲[1] 

机构地区：[1]四川大学华西医院医学遗传研究室,成都610041

出　　处：《中华医学遗传学杂志》2001年第6期482-485,共4页Chinese Journal of Medical Genetics

基　　金：国家自然科学基金重大项目 (3999342 0 ) ;卫生部科学研究基金 (98- 1 - 2 0 9) ;四川大学华西医院科研基金 (2 0 0 0 1 9)~~

摘　　要：数据库在遗传多态研究中有着十分重要的作用。为满足我国医药学界人类基因组多态性研究的需要 ,四川省疾病基因组学与法医学重点实验室和北京大学生命科学院国家生物信息中心合作 ,建成了国内第 1个人类基因组多态数据库 Go! Poly。该数据库为基因取向的数据库 ,并具有一系列的特点。Databases play an important role in the study of genetic polymorphism. To meet the need for more studies of human genome polymorphism by Chinese medical and pharmaceutical community, a gene oriented human genome polymorphism database-Go! Poly was constructed. As a generalized polymorphism database, Go! Poly extracted human gene-linked sequence variations of all common types from various public resources including scientific journals and Web resources such as HGBASE (http:// hgbase. cgr. ki. se) and dbSNP (http.//www. ncbi. nlm. nih. gov/SNP/). The polymorphism data were then categorized into different gene loci, and the reference sequences given by LocusLink were used as positioning reference. To facilitate the use, a friendly web interface and a text based query strategy were implemented. Users can fetch specific polymorphism data in just three steps: find specific gene locus by simple search, display sequence variation information of a specific gene locus select, and view the final result of a specific variation site. Besides, a web-based submission tool is provided for direct submission, which can make the polymorphism information generated by the Chinese scientific community available from this resource.

关 键 词：DNA数据库 遗传多态性 单核苷酸多态性 人类基因组 

分 类 号：Q987[生物学—遗传学]