正常妇女月经不同时期乳腺超声影像特点与血清雌、孕激素水平的关系  

Features of Breast Ultrasound Image and Its Correlation with Estradiol and Progesterone Level in Different Phases of Menstrual Cycle in Normal Women

作　　者：周远征[1] 姜玉新[1] 孙强[1] 张淑琴[1] 张颖[1] 陈凤领[1] 林守清[1] 

机构地区：[1]中国医学科学院中国协和医科大学协和医院妇产科,北京100730

出　　处：《中国医学科学院学报》2001年第6期609-613,共5页Acta Academiae Medicinae Sinicae

摘　　要：目的观察正常妇女不同月经时期的乳腺超声影像特点,分析其与血清雌、孕激素水平的关系。方法50名25～45岁月经正常、未发现乳腺疾患的妇女,记录近3个月经周期中乳腺胀疼出现的时间及持续时间,分别于月经前3～7d(黄体期)和月经周期第9～12天(晚卵泡期)进行乳腺超声检查,测量乳腺腺体层厚度、导管宽度、乳腺腺体结构及血流,并于超声检查当日取血,用磁分离酶免法测血清雌二醇(E2)、孕酮(P)水平。结果黄体期乳腺腺体层较晚卵泡期厚7.3%,而晚卵泡期导管较黄体期宽13%,但二者差异无显著性;24名(48%)有乳腺结构改变;30名(60%)有乳房胀疼,皆于月经前出现,平均持续4d,其中19名(63.3%)有乳腺腺体结构改变;无乳腺胀疼20名中仅5名(25%)有结构改变(χ2,P<0.01)。有、无乳房胀疼者其黄体期血清E2水平分别为365.0pmol/L和335.3pmol/L(P>0.05);P水平分别为73.3nmol/L和66.1nmol/L(P>0.05);晚卵泡期E2水平分别为299.9pmol/L和385.8pmol/L(P=0.05);有、无乳腺结构改变者其黄体期血清E2水平分别为368.1pmol/L和322.7pmol/L(P<0.05),P水平分别为78.8nmol/L和62.2nmol/L(P=0.05);晚卵泡期E2水平分别为301.9pmol/L和364.2pmol/L(P>0.05)。结论乳腺腺体声像图表现随月经周期而变化;乳房胀疼与乳腺腺体结构改变相关;Objective To determine the features of the breast ultrasound image and its correlation with estro-gen and progestogen level during different phases of menstrual cycle in normal women.Methods Br east ultrasound was performed during luteal phase and late follicular phase in50women aged25～45,with normal menstrual cycle and no distinct breast disease.Breast section thickness,ductal width,breast structure and blood flow were measured.Initial time and persistent days of the cyclic breast pain were recorded.Serum estradiol(E 2 )and progesterone (P)levels were measured by enzyme immunoassay on the day of ultrasound performed.Results Breast glandular section was thicker(increasing by7.3%)in luteal phase than that in late follicular phase and breast ductal was wider(in creasing by13%)in late follicular phase than that in luteal phase.However,both of them had no sign if icant difference.Thirty women(60%)experienced cyclic premenstrual mastalgia,lasting4days.Twenty four women(48%)had breast structure changes,nineteen(63.3%)of30women with cyclic ma stalgia,but only5(25%)of20women without breast pain had breast structure change(χ 2 ,P<0.01). Ave rage serum E 2 level of women with or without cyclic breast pain in luteal phase were365.0pmol/L and335.3pmol/L respectively (P>0.05),serum progesterone level were73.3nmol/L and66.1nmol/L respectively(P>0.05).Serum E 2 levels of women with or without cyclic breast pain in late follicu lar phase were299.9pmol/L and385.8pmol/L respectively (P=0.05).Average serum E 2 levels of women with or without breast structure change in luteal phase were368.1pmol/L and322.7pmol/L respectively(P<0.05).Serum P levels were78.8nmol/L and62.2nmol/L respectively(P=0.05);Estradiol levels in late follicular phase were301.9pmol/L and364.2pmol/L respectively(P>0.05).Conclusions Image of breast ultrasound changed following menstrual cycle in normal menstrual wom en.Breast structure changes is related to breast pain.Breast pain and bre ast structure changes may be

关 键 词：乳腺 彩色多普勒超声 雌激素 孕激素 月经生理 妇女 

分 类 号：R711.51[医药卫生—妇产科学]