莪术、三棱对人肺癌细胞凋亡的影响  

Effect of Rhizoma Curcumate Zedoariae and Herbra Trifolii Repentis on Apoptosis of Human Lung Cancer Cell Line A549

作　　者：王喆[1] 张瑾峰[1] 付桂芳[1] 

机构地区：[1]首都医科大学细胞与遗传学教研室

出　　处：《首都医科大学学报》2001年第4期304-305,共2页Journal of Capital Medical University

摘　　要：运用EPICS ELITE型流式细胞仪 ,研究莪术、三棱对人肺癌A5 49细胞凋亡的诱导作用。实验共设莪术提取液组、三棱提取液组及二者协同作用组 3组。结果显示 ,莪术、三棱对人肺癌细胞的凋亡有诱导作用。提示诱导肿瘤细胞的凋亡可能是莪术、三棱抑癌作用的机制之一。The object was to study the mechanism of inhibitory and tumor killing effects of two kinds of Chinese traditional herbs, rhizoma curcumate zedoariae and herbra trifolii repentis. Lung cancer cell line A549 was adopted as target cell. The reseach examined tumor cell apoptosis induced by the herbs with flow cytometry when the target cell was cultured with the herb substration for 24 h. The substraction both two kinds of herbs can induce tumor cell apoptosis. The great synergic effect to induce target cell apoptosis was also found out. The results suggested that to induce target cells apoptosis is the main mechanism to inhibit and kill tumor by the herbs.

关 键 词：莪术 三棱 人肺癌细胞 细胞凋亡 肺肿瘤 抗癌药 

分 类 号：R979.1[医药卫生—药品] R734.2[医药卫生—药学]