人巨细胞病毒感染与自然流产关系的研究  

Study on Relationship Between Infection of Human Cytomegalovirus(HCMV) and Spontaneous Abortion

作　　者：毛琳[1] 李向群[1] 侯炜[1] 申元英[1] 邓子琴[1] 李宗山[1] 杨占秋[1] 

机构地区：[1]湖北医科大学病毒所临床病毒室,武汉430071

出　　处：《中国公共卫生》2002年第2期167-168,共2页Chinese Journal of Public Health

摘　　要：目的　探讨人巨细胞病毒 (HCMV)感染与自然流产之间的关系。方法　应用酶联免疫吸附试验 (ELISA)及聚合酶链试验 (PCR)检测 39例自然流产患者 (流产组 )血清中HCMV -IgM及外周血、胎儿组织中HCMV -DNA ,并选择 2 3例人工流产孕妇做对照组。结果　流产组患者血清中HCMV -IgM、外周血、胎儿组织HCMV -DNA阳性率分别为 38 4 6 %、43 5 8%、33 33%。对照组分别是 8 6 9%、8 6 9%、4 31%。两者比较差别有显著性意义 (P <0 0 5 )。结论　HCMV感染是引起自然流产的重要原因之一。Objective To investigate the relationship between infection of human cytomegalovirus and spontaneous abortion.Methods Patients HCMV-IgM in sera and HCMV-DNA in peripheral blood cells and in fetal tissues were detected by ELISA and PCR in 39patients with spontaneacs abortion,respectively.So were the 23 cases with artifical abortion as control groupu.Results Patients' positive rates of HCMV-IgM and HCMV-DNA in peripheral blood cells and in fetal tissus among patients with spontaneous abortion were 38.46%,43.58%,33.33%,respectively,and the control group's postive rates were 8.69%,8.69% and 4.31%,respectively.The positive rates were significantly different between two groups(P<0.05).Conclusion HCMV infection played an important role in spontaneous abortion.

关 键 词：人巨细胞病毒 自然流产 IGM抗体 核酸 HCMV PCR法 

分 类 号：R373[医药卫生—病原生物学] R714.21[医药卫生—基础医学]