褪黑素和电针对创伤大鼠免疫功能的影响  

Effect of Melatonin and Electroacupuncture on Immune Function of Traumatic Rat s

作　　者：黄颖苏[1] 姜建伟[1] 吴根诚[1] 曹小定[1] 

机构地区：[1]复旦大学医学院神经生物学教研室,上海200032

出　　处：《针刺研究》2001年第3期233-234,共2页Acupuncture Research

摘　　要：Trauma stress is a well known entity and may be defined as a threat to the immune function. The effect of melatonin(MT) and electroacupuncture(EA) treatme nt on the cytotoxic activity of natural killer(NK) cells, the proliferative resp onse of spleen lymphocytes to ConA and the dynamic changes of the induction of i nterleukin 2(IL 2) in traumatic rats were evaluated in this study.The results showed that 5 mg/kg (ip)melatonin was able to recover the lowered NK c ell activity in trauma rats 24 hours after operation (P<0.05).Al so lymphoc yte proliferation and the induction of IL 2 production were reversed by MT trea tment (P<0.05,P<0.05).EA stimulation of "Zusanli"(ST 36) a nd "Lanwei"(Extra 37) points also obviously improved the immunosuppression pro duced by trauma. MT combined wit h EA could further modulate the depressed immune function(P<0.01), whi ch was significantly superior to melatonin or EA alone (P<0.05, P<0.05). These results indicate that MT and/or EA can recover NK cel l activity,lymphocyte proliferative capacity and the induction of IL 2 producti on,but the mechanism deserves further investigation.Trauma stress is a well known entity and may be defined as a threat to the immune function. The effect of melatonin(MT) and electroacupuncture(EA) treatme nt on the cytotoxic activity of natural killer(NK) cells, the proliferative resp onse of spleen lymphocytes to ConA and the dynamic changes of the induction of i nterleukin 2(IL 2) in traumatic rats were evaluated in this study.The results showed that 5 mg/kg (ip)melatonin was able to recover the lowered NK c ell activity in trauma rats 24 hours after operation (P<0.05).Al so lymphoc yte proliferation and the induction of IL 2 production were reversed by MT trea tment (P<0.05,P<0.05).EA stimulation of 'Zusanli'(ST 36) a nd 'Lanwei'(Extra 37) points also obviously improved the immunosuppression pro duced by trauma. MT combined wit h EA could further modulate the depressed immune function(P<0.01), whi ch was significantly superior to melatonin or EA alone (P<0.05, P<0.05). These results indicate that MT and/or EA can recover NK cel l activity,lymphocyte proliferative capacity and the induction of IL 2 producti on,but the mechanism deserves further investigation.

关 键 词：褪黑素 电针 创伤 动物实验 免疫功能 

分 类 号：R245.0[医药卫生—针灸推拿学]