中医肝病各证患者的血浆环核苷酸变化  

Plasma Cyclic Nucleotide Alteration In Patients with Different Gan Zheng

作　　者：黎杏群[1] 李学文[1] 陈泽奇[1] 石林阶[1] 李家邦[1] 胡随瑜[1] 陈昌华[1] 张海男[1] 张翔[1] 殷全荣[1] 张花先[1] 

机构地区：[1]中南大学湘雅医学院,湖南长沙410008

出　　处：《湖南中医学院学报》2001年第2期4-6,共3页Journal of Hunan College of Traditional Chinese Medicine

基　　金：国家自然科学基金!资助重点项目 (39330 2 40 )

摘　　要：用放射免疫法测定 16 4例中医肝病各证型的血浆环核苷酸含量 ,与健康人 37例比较 ,发现肝气郁结证、肝阳上亢证、肝阳化风证、肝火上炎证、肝血虚证均呈cGMP升高 ,cAMP变化无显著性差异 ,cAMP/cGMP比值降低 ,提示与植物性神经递质释放水平有关。We determined cAMP,cGMP concentration in plasma by radioimmunoassay in 164 cases of different syndromes of hepatopathy (Gan Zheng) (29 cases of Ganqiyujie Zheng (GQRJZ),17 of Ganyangshangkang Zheng (GYSKZ),32 of Ganyanghuafeng Zheng (GYHFZ),59 of Ganhuoshangyan Zheng (GHSYZ) and 27 of Ganxuexu Zheng (GXXZ)) Compared with 37 healthy controls,it was found that the contents of cGMP in plasma of all the patients with above five Zheng were increased and the cAMP/cGMP ratio decreased significantly,but the contents of cAMP in all Zheng showed no significant difference The results suggest that plasma cyclic nucleotide alteration might be related to increased release of catecholmines in Gan Zheng as a manifestion of sympathetic hyperfunction

关 键 词：肝气郁结证 肝阳上亢证 肝阳化风证 肝火上炎证 肝血虚 环核苷酸 肝病 中医 

分 类 号：R256.4[医药卫生—中医内科学]