大鼠实验性败血症后的多器官损伤  

MULTIPLE ORGAN DAMAGE AFTER EXPERIMENTAL SEPSIS IN RATS

作　　者：钱睿哲[1] 郝刚[2] 阎友珍[1] 王疁画 金惠铭[1] 

机构地区：[1]上海医科大学基础医学部病理生理学教研室 [2]兰州医学院病理生理学教研室 [3]上海医科大学医学系86级5班

出　　处：《上海医科大学学报》1991年第6期417-420,22,共5页Journal of Fudan University(Medical Science)

基　　金：上海医科大学青年科研基金资助(90-11)

摘　　要：用盲肠结扎加穿刺的方法复制大鼠早期多器官衰竭(MOF)模型,作者称其为败血症后多器官损伤。此模型复制后20h,大鼠腹腔器官出现不同程度的形态和功能异常,用激光多普勒微循环血流计测定败血症组及对照组腹腔器官表面血流量的结果表明,败血症组除肝脏外,脾、肾、小肠及尾部微循环血液灌流量均有明显降低。作者介绍了用此方法制作这种动物模型的优点并认为腹腔器官微循环灌流量降低是MOF早期的发病机制之一。An animal model of multiple organ damage after experimental sepsis was created by cecal punctures after its ligation in rats. 20 hours after cecal ligation, morphological and functional changes in the abdominal viscera in varying degrees appeared. Superficial blood flow in the abdominal viscera was measured by means of Laser Doppler Flowmeter. Results indicated that in the septic group, the microcirculation perfusion in spleen, kidney, small intestine and tail significantly decreased (P<0.01 or 0.05) but nor in the liver. The authors suggested that this was an animal model of multiple organ failure (MOF) in early stage and the disturbance of microcirculation perfusion in the abdominal viscera was one of the mechanisms in pathogenesis of MOF.

关 键 词：败血症 多器官损伤 穿刺 

分 类 号：R515.3[医药卫生—内科学]