广西不同煤质和围岩粉尘对大鼠肺纤维化病变的研究  

Study on pulmonary fibrogenicity in rats by different kinds of coal and country rock dust in Guangxi province

作　　者：杨莉[1] 吴开国[1] 林秀月[1] 

机构地区：[1]广西医科大学公共卫生学院,广西南宁530021

出　　处：《中国职业医学》2001年第5期15-18,共4页China Occupational Medicine

摘　　要：目的　探讨不同煤种煤尘致病性的特点 ,确定影响煤尘致病性的主要因素。方法　采用广西烟煤、无烟煤和褐煤不同煤种粉尘制作大鼠尘肺模型 ,从生化指标来探讨不同的煤种粉尘与尘肺的发病关系。结果　染尘大鼠肺冲洗液中酸性磷酸酶、乳酸脱氢酶 ,肺组织中脂质过氧化物、胶原蛋白含量均为石英组最高 ,其次依次是烟煤组、无烟煤组、褐煤组 ,最低为正常对照组 ,结果差异有显著性 (P <0 0 1)。结论　围岩煤尘具有一定的致病性 ,但较石英弱 ,其致病性强弱与煤质优劣无关 。Objective To explore the characteristic of pathogenicity in different kinds of coal dust and define main factors of pathogenicity. Methods Using different kinds of coal dust animal models in Guangxi province to explore the relation of pneumoconiosis and biochemistry patterns. Results The acid phosphatase (ACP) and lactate dehydrogenase(LDH) in bronchoalveolar lavage fluid, LPO and the collagen levels in the pulmonary tissue of the experiment rats showed that silica dust group was the highest, the bitulminous coal dust group came the next, and then the anthracite coal dust group and brown coal dust group were the ones with lesser extent, finally the physiological salines group was the lowest. Conclusion The coal dust might have certain pathogenicity but weaker than that of silica. The coal dust pathogenicity would have no relationship with its metamorphic degree and did relate to the contents of SiO 2.

关 键 词：煤尘 二氧化矽 肺纤维化 

分 类 号：R135.2[医药卫生—劳动卫生]