通瘀Ⅰ号方改善老年糖尿病患者血栓前状态的临床研究  

Clinical Study on Effect of Tongyu No. I in Improving Prethrombotic State of Senile Diabetes Mellitus

作　　者：朱良争[1] 宋菊敏[2] 何颂华[1] 钟家宝[1] 徐蓉娟[1] 庞惠芳 卜建宏 廖菡[2] 王丽芬 

机构地区：[1]上海中医药大学附属龙华医院,上海200032 [2]上海中医药大学基础医学院

出　　处：《中国中西医结合杂志》2001年第11期810-812,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：上海市卫生局资助课题 (No .974L0 4 )

摘　　要：目的 :探讨中药通瘀Ⅰ号方改善老年糖尿病血栓前状态的作用机理。方法 :选择有血栓前状态伴有瘀血证的老年糖尿病患者 62例 ,随机分为两组 ,在常规基础治疗上分别加用通瘀Ⅰ号方 (中药组 32例 )和肠溶阿司匹林 (对照组 30例 )治疗 2个月 ,并观察两组患者症候疗效及治疗前后的相关指标。结果 :中药组显效 14例 ,有效 16例 ,无效 2例 ,总有效率为 93 8% ;对照组分别为 6例、14例、10例和 66 7% ;两组总有效率比较 ,差异有显著性 (P <0 0 1)。中药组血栓素B2 下降程度与对照组相似 ,中药组的血小板颗粒膜蛋白 (GMP 140 )、空腹血糖水平较治疗前明显下降 (P <0 0 1) ,治疗后两组比较 ,差异均有显著性 (P <0 0 5 )。结论 :通瘀Ⅰ号方能改善糖尿病的血栓前状态和糖尿病瘀血证候。其主要作用机理可能与改善GMPObjective: To explore the therapeutic mechanism of Tongyu No. I (TY 1) in improving prethrombotic state of senile diabetes mellitus. Methods: Sixty two patients of diabetes mellitus with prethrombotic state and blood stasis Syndrome were selected and divided randomly into two groups, 32 in the treated group and 30 in the control group. The two groups were treated by conventional therapy, combined with additional TY 1 (treated group) and aspirin (control group) respectively for 2 months. And the clinical effect as well as relevant criteria in both groups before and after treatment were observed. Results: In the treated group, treatment showed markedly effective in 14 cases, effective in 16 and ineffective in 2, the total effective rate being 93.8%. In the control group,the corresponding values were 6, 14, 10 and 66.7% respectively. Comparison of the total effective rate in the two groups showed significant difference (P<0 01). After treatment, the treated group showed lowering in plasma TXB 2 similar to that in the control group, while the decrease of GMP 140 and fasting blood glucose levels was significant as compared with before treatment (P<0 01) and the difference was significant between the two groups (P<0 05) after treatment. Conclusion: TY 1 could improve the prethrombotic state and blood stasis Syndrome in patients of diabetes mellitus, the main therapeutic mechanism might be correlated to the lowering of GMP 140 content.

关 键 词：通瘀I号方 老年 糖尿病 血栓前状态 瘀血证 血小板颗粒膜蛋白 

分 类 号：R259.871[医药卫生—中西医结合] R289.5[医药卫生—中医内科学]