金水六君煎对慢性支气管炎小鼠血清超氧化物歧化酶活力和丙二醛含量的影响  

Study on Effect of Jinshui Liujun Jian Oral Liquid on Serum Superoxide Dismutase Activity and Malonyldialdehyde Content in Mice with Chronic Bronchitis

作　　者：赵长鹰[1] 沈英森[2] 孟辉[2] 唐颖[2] 陈再智[3] 陈小娟[3] 陈丽娟[3] 

机构地区：[1]暨南大学医学院第一附属医院中医针灸培训中心,,广州510630 [2]暨南大学医学院中医系 [3]广东省药物研究所

出　　处：《中国中西医结合杂志》2001年第11期843-844,共2页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国务院侨办立项 (No.93 - 98- 6)

摘　　要：目的 :探讨金水六君煎口服液对慢性支气管炎小鼠血清超氧化物歧化酶 (SOD)活力及丙二醛 (MDA)含量的影响。方法 :采用烟熏方法复制慢性支气管炎模型小鼠 ,并用金水六君煎口服液治疗 ,检测小鼠血清SOD活力与MDA含量。结果 :金水六君煎口服液高剂量组SOD活力〔(0 67± 0 15 )NU/L〕增高 ,与模型组〔(0 39± 0 13)NU/L〕比较 ,差异有显著性 (P <0 0 1) ;MDA含量〔(9 2 6± 2 90 )nmol/L〕降低 ,与模型组〔(16 0 7± 5 62 )nmol/L〕比较 ,差异有显著性 (P <0 0 1)。结论Objective: To study the effect of Jinshui Liujun Jian Oral Liquid (JLJOL) on serum superoxide dismutase (SOD) activity and malonyldialdehyde (MDA) content in mice with chronic bronchitis.Methods: JLJOL was given to the chronic bronchitis mice model (induced by smoking) through gastrogavage, and then SOD activity and MDA content were tested. Results: SOD activity in model mice after JLJOL treatment was 0 67±0 15 NU/L, which was significantly higher than that in the untreated model (0 39±0 13 NU/L, P<0 01). But the MDA content in treated mice was significantly lower than that in untreated one (9 26±2 90 nmol/L vs 16 07±5 62 nmol/L, P<0 01). Conclusion: JLJOL could scavenge the injury of free radical on organism.

关 键 词：金水六君煎 慢性支气管炎 血清超氧化物歧化酶 丙二醛 

分 类 号：R259.622.1[医药卫生—中西医结合] R289.5[医药卫生—中医内科学]