钙拮抗剂对体外培养中大鼠胰岛细胞胰岛素分泌的影响  

THE EFFECTS OF CALCIUM ANTAGONISTS ON INSULIN SECRETION IN NEONATAL RAT PANCREATIC ISLET CELL MONOLAYER CULTURES

作　　者：顾明君[1] 朱禧星[2] 钟学礼 方京冲[2] 何德华[2] 

机构地区：[1]第二军医大学附属长征医院内分泌科 [2]上海医科大学附属华山医院糖尿病研究室

出　　处：《上海医学》1991年第9期522-524,共3页Shanghai Medical Journal

摘　　要：维拉帕米、硝苯啶及硫氮(艹卓)酮人体治疗血浓度(25～100ng/ml)与培养7.5天新生大鼠胰岛细胞单层培养物保温3小时,各药浓度25ng/ml 不抑制胰岛素分泌,50及100ng/ml 明显抑制胰岛素分泌。3药(100ng/ml)抑制胰岛素分泌程度及可逆程度差别无统计学意义。The effects of verapamil(VER),nifedipine(NIF)and diltiazem(DIL)on insulin s(?)cretion(IS)in neonatal rat pancreatic islet cell monolayer cultures were investigated.IS wasnot affected after 3-hr incubation in the medium containing 25ng/ml of VER,NIF or DIL, but IS was inhibited at 50 or 100ng/ml of VER,NIF(?)r DIL.However,after a further14-hr incubation in the drug-free medium,IS recovered fully.The reversible inhibtory ef-fect showed no significant difference at 100ng/ml concentration of each drug.

关 键 词：钙拮抗剂 胰岛素 胰岛细胞 

分 类 号：R962[医药卫生—药理学]