冠心病患者血清HCMV抗体的检测及临床意义  

Detection and Significance of HCMV Antibody in Patients with Coronary Heart Diseases

作　　者：黄从新[1] 江洪[1] 王德胜[1] 尹丽娅[1] 杨波[1] 王晶[1] 伍远雄[1] 李庚山[1] 

机构地区：[1]武汉大学人民医院心内科,武汉430060

出　　处：《武汉大学学报（医学版）》2001年第4期360-361,366,共3页Medical Journal of Wuhan University

基　　金：湖北省自然科学基金资助课题;批准号 :93J74

摘　　要：目的 :探讨动脉粥样硬化及血管成形术后再狭窄发生的危险因子与可能的机制。方法 :采用酶联免疫学方法测定冠心病患者PTCA术前术后血浆抗HCMV抗体的水平。结果 :术前、术后HCMV的急性感染率较低 (2 5 /2 6例术前术后HCMV的IgM抗体均为阴性 ) ,但慢性感染率较高 (2 1/2 6例抗HCMV的IgG抗体为阳性 ) ,11例患者PT CA术后的IgG抗体水平较术前均有提高 ,差别具有统计学意义 ;而SCA组的患者的IgG抗体水平与术前比较 ,差别无统计学意义。PTCA患者中抗HCMV抗体IgG水平的差别 :HCMV抗体阳性的患者中 3/12例IgG抗体的OD值很高 ,最高的可达 1.871,提示部分患者对HCMV的免疫反应较强烈。结论 :HCMV感染可能是AS与冠心病患者PTCA术后再狭窄发生的危险因子 。Abstract: To study the possibility of human cytomegalovirus (HCMV) infection as a risk factor in the initiation and progression of both atherosclerosis and restenosis after percutaneous transluminal coronary angioplasty (PTCA). Methods: To detect antibodies of HCMV among patients with coronary heart diseases (CHD) by Enzyme Linked Immuno Sorbent Assay (ELISA). Results: Before and after PTCA or SCA (selected coronary angiography), IgM antibodies of HCMV were negative in 25/26 cases, while IgG antibodies of HCMV positive in 21/26 cases. Among 11 cases receiving PTCA, levels of IgG on HCMV were higher after operation than that before operation. Levels of IgG in 3 cases were extraordinary high (the highest OD up to 1.871), while HCMV IgG level differences before and after SCA were not statistical significance. Conclusions: HCMV infection is associated with coronary heart diseases. HCMV infection may be a risk factor in the initiation and progression of AS and restenosis after PTCA.

关 键 词：冠状动脉疾病 巨细胞病毒 抗体 血清诊断 冠心病 HCMV抗体 

分 类 号：R541.4[医药卫生—心血管疾病] R446.62[医药卫生—内科学]