HBV前S_2抗原、前S_2抗体与其病毒标志物的关系  

Relationship between HBV Pre-S_2 Antigen,Pre-S_2 Antibody and Its Virus Makers

作　　者：游景韩[1] 

机构地区：[1]福建省肿瘤医院检验科,福建福州350014

出　　处：《现代诊断与治疗》2001年第4期202-204,共3页Modern Diagnosis and Treatment

摘　　要：目的　探讨乙型肝炎患者前S2 抗原、抗体与HBVM、HBV DNA之间关系。方法　对 14 6例乙型肝炎患者用ELISA法检测前S2 抗原、前S2 抗体及乙型肝炎病毒标志物 (HBVM ) ;用聚合酶链反应 (PCR)法检测乙型肝炎病毒HBV DNA。结果　急性肝炎、慢性肝炎、肝硬变患者前S2 抗原检出率分别为 8.33 %、71.96 %、77.0 7% ;前S2 抗体的检出率分别为 75 %、9.34%、3 .7%。前S2 抗原在HBV DNA、HBeAg阳性病例中检出率明显高于阴性组 (P <0 .0 0 1)。前S2 抗体阳性病例HBV DNA、HBeAg均为阴性。 结论　前S2 抗原的检出意味着病毒有复制或有传染性。前S2 抗体的出现标志着病毒被清除 ,在慢性肝病中检出并不意味病情稳定 ,同时发现该抗体可以在急性乙型肝炎急性期及血清HBVM全部阴性的患者中检出。Objective To investigate the relationship between HBV Pre S 2 antigen,Pre S 2 antibody and its virus makers(HBV M).Method Pre S 2 Antigen,Pre S 2 Antibody and HBV M were examinated on 146 cases of hepatitis B by ELISA,Hepatitis B virus DNA(HBV DNA) was examinated by polymerase chain reaction(PCR).Results Positive rate of Pre S 2 antigen in acute hepatitis,chronic hepatitis and cirrhosis cases was 8.33%,71.96%,77.07% respectively,and that of Pre S 2 antibody in the above cases was 75%,9.34%,3.7% respectively.The positive rate of Pre S 2 antigen in positive HBV DNA and HBeAg cases were obviously higher than that in the negative ones( P <0.001).In positive Pre S 2 antibody cases,both HBV DNA and HBeAg were negative.Conclusions When Pre S 2 antigen is found,the viruses are reproductive and infectious.When Pre S 2 antibody is found the viruses have been eliminated,but it doesnt mean that chronic hepatitis B cases is stable.The Pre s 2 antibody can be found in the acute period of acute hepatitis B cases,and also in those whose HBV M were all negative.

关 键 词：乙型肝炎 HBV 前S2抗原 前S2抗体 病毒标志物 

分 类 号：R512.62[医药卫生—内科学]