临床各型病毒性肝炎血清肿瘤坏死因子检测及意义  

Significance of Assaying Serum Level of TNF on Patients with Various Type of Viral Hepatitis

作　　者：张新萍[1] 徐建亮[1] 刘宝根[1] 

机构地区：[1]浙江省杭州市第六人民医院病毒免疫室,杭州310014

出　　处：《中国临床医学》2001年第6期660-660,662,共2页Chinese Journal of Clinical Medicine

摘　　要：目的 :探讨血清肿瘤坏死因子 (TNF α)在不同临床分型的病毒性肝炎患者血清中的含量及临床意义。方法 :采用双抗体夹心酶联免疫吸附试验检测 175例病毒性肝炎患者血清TNF α水平。结果 :175例肝炎病人中 ,急性重型肝炎 15例 ,TNF α平均含量 8.0 9± 1.85ng/ml;慢性肝炎 76例 ,其临床分型及TNF α平均含量分别是 :2 2例重度慢性肝炎 5 .94± 1.87ng/ml,2 4例中度慢性肝炎 5 .5 2± 1.6 7ng/ml,30例轻度慢性肝炎 3.0 3± 1.0 2ng/ml;肝炎肝硬化 14例 4.71± 1.2 7ng/ml;急性肝炎40例 1.0 2± 0 .35ng/ml;无症状乙肝病毒携带者 30例 0 .90± 0 .2 1ng/ml。结论 :除乙肝病毒携带者及急性肝炎的检测结果与对照组相比较无差异外 ,其余临床各型病毒性肝炎 (慢性肝炎、肝硬化、急性重型肝炎 )均有显著差异 ,在与其它检测指标配合下 ,血清TNFObjective: Studying the significance of serum TNF level in different clinical types of viral hepatitis. Methods: Sandwich ELISA was used to assay serum TNF level in 175 cases of viral hepatitis patients. Results: Serum TNF level was 8.09ng/ml in 15 cases of acute fulminant hepatitis, 5.94ng/ml in 22 cases of severe chronic hepatitis, 5.52ng/ml in 24 cases of medium chronic hepatitis, 3.03ng/ml in 30 cases of mild chronic hepatitis, 4.71ng/ml in 14 cases of viral hepatic cyrrhosis, 1.02ng/ml in 40 cases of acute hepatitis and 0.90ng/ml in 30 cases of asymptomatic HBV carrier. Conclusion: The serum TNF level has sinificant difference between case group and control group among patients with CH, liver cirrhosis and acute fulminant hepatitis, while in ASC and AH group there is no significant difference between case and control group. It is indicated that the assaying serum TNF level can be used to monitor the severity of liver damage and make the prognosis in various types of viral hepatitis.

关 键 词：血清 肿瘤坏死因子 TNF-Α 病毒性肝炎 

分 类 号：R512.6[医药卫生—内科学]